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Details on Person Gamma-secretase cleaves YBX1:NOTCH3

Class:Id	BlackBoxEvent:9017817
_displayName	Gamma-secretase cleaves YBX1:NOTCH3
_doRelease	TRUE
_timestamp	2017-11-10 17:24:47
authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
catalystActivity	[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9017816] Orlic-Milacic, Marija, 2017-08-25
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
goBiologicalProcess	[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
input	[Complex:9017807] YBX1:NOTCH3 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9017794] YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation
modified	[InstanceEdit:9017878] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9024182] Orlic-Milacic, Marija, 2017-10-02 [InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9028853] Orlic-Milacic, Marija, 2017-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Gamma-secretase cleaves YBX1:NOTCH3
output	[EntityWithAccessionedSequence:157647] NICD3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9017797] NOTCH3 binds YBX1 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9017819] R-HSA-9017817.2
summation	[Summation:9017818] Binding of NOTCH3 to YBX1 (YB-1) triggers cleavage of NOTCH3...
(hasEvent)	[Pathway:9017802] Noncanonical activation of NOTCH3 [Homo sapiens]
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No pathways have been reviewed or authored by Gamma-secretase cleaves YBX1:NOTCH3 (9017817)