THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE.
WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P07953 Pfkfb1
Class:Id
ReferenceGeneProduct:90177
_chainChangeLog
initiator methionine:1 added on Sat February 7 2015;chain:2-471 added on Sat February 7 2015;initiator methionine:1 for 90177 removed on Fri Nov 03 2023;initiator methionine: for 90177 added on Fri Nov 03 2023;initiator methionine: for 90177 removed on Fri Aug 15 2025;initiator methionine:1 for 90177 added on Fri Aug 15 2025
_displayName
UniProt:P07953 Pfkfb1
_timestamp
2025-08-15 21:29:57
chain
initiator methionine:1 chain:2-471
checksum
E307AF13945E0FCD
comment
FUNCTION Synthesis and degradation of fructose 2,6-bisphosphate.CATALYTIC ACTIVITY beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphateCATALYTIC ACTIVITY beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + H(+)ACTIVITY REGULATION Phosphorylation at Ser-33 inhibits the kinase and activates the bisphosphatase.SUBUNIT Homodimer.INTERACTION Liver.SIMILARITY In the C-terminal section; belongs to the phosphoglycerate mutase family.
