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Details on Person RHOJ GEFs activate RHOJ

Class:Id	Reaction:9017491
_displayName	RHOJ GEFs activate RHOJ
_doRelease	TRUE
_timestamp	2021-06-11 00:17:41
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9017492] guanyl-nucleotide exchange factor activity of RHOJ GEFs [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9017489] Orlic-Milacic, Marija, 2017-08-21
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
input	[Complex:9017484] RHOJ:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:9693307] Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells [LiteratureReference:9693301] Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology [LiteratureReference:1012975] Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
modified	[InstanceEdit:9693308] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9693315] Orlic-Milacic, Marija, 2020-06-30 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714871] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733832] Orlic-Milacic, Marija, 2021-06-10 [InstanceEdit:9733841] Orlic-Milacic, Marija, 2021-06-10 [InstanceEdit:9733843] Orlic-Milacic, Marija, 2021-06-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RHOJ GEFs activate RHOJ
output	[Complex:9017485] RHOJ:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9017497] R-HSA-9017491.3
summation	[Summation:9693313] DOCK8 guanine nucleotide exchange factors (GEFs) was shown t...
(hasEvent)	[Pathway:9013409] RHOJ GTPase cycle [Homo sapiens]
(precedingEvent)	[Reaction:9017488] RHOJ GAPs stimulate RHOJ GTPase activity [Homo sapiens] [Reaction:9017507] RHOJ binds effectors at the plasma membrane [Homo sapiens]
(replacementInstances)	[_Deleted:9768327] Deletion of instance: 194913
(updatedInstance)	[_UpdateTracker:9775522] Update Tracker - [Reaction:9017491] RHOJ GEFs activate RHOJ - v78:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by RHOJ GEFs activate RHOJ (9017491)