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Details on Person Full-length Interleukin-33 (IL33) but not processed forms is...

Class:IdSummation:9017202
_displayNameFull-length Interleukin-33 (IL33) but not processed forms is...
_timestamp2017-10-20 10:20:04
created[InstanceEdit:9017199] Duenas, Corina, 2017-08-17
literatureReference[LiteratureReference:9015507] The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription
[LiteratureReference:8981778] IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway
[LiteratureReference:448595] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
[LiteratureReference:5690301] Nuclear IL-33 is a transcriptional regulator of NF-?B p65 and induces endothelial cell activation
modified[InstanceEdit:9017204] Duenas, Corina, 2017-08-17
[InstanceEdit:9023427] Duenas, Corina, 2017-09-27
[InstanceEdit:9024305] Duenas, Corina, 2017-10-03
[InstanceEdit:9024502] Duenas, Corina, 2017-10-05
[InstanceEdit:9026384] Jupe, Steve, 2017-10-19
[InstanceEdit:9026541] Jupe, Steve, 2017-10-20
textFull-length Interleukin-33 (IL33) but not processed forms is reported to bind the p65 (RELA) subunit of Nuclear factor kappa-B (Ali et al. 2011).
Mast cells stimulated with IL33 or PMA/ionomycin show phosphorylation of IRAK1, TAK1, and NF-κB, but this was not observed in basophils (Kroeger et al. 2009, Schmitz et al. 2005).
There is also evidence that IL33 binds to the RELA promoter region (Choi et al. 2012).
(summation)[BlackBoxEvent:9016605] Unconfirmed - IL33 binds NFKB1(1-433):RELA [Homo sapiens]
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