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Details on Person Full-length Interleukin-33 (IL33) binds Caspase- 1, Caspase-...

Class:IdSummation:9016604
_displayNameFull-length Interleukin-33 (IL33) binds Caspase- 1, Caspase-...
_timestamp2017-10-20 10:20:02
created[InstanceEdit:9016613] Duenas, Corina, 2017-08-14
literatureReference[LiteratureReference:8981655] Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
[LiteratureReference:9016608] The enigmatic processing and secretion of interleukin-33
[LiteratureReference:9017197] The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
modified[InstanceEdit:9016658] Duenas, Corina, 2017-08-14
[InstanceEdit:9017199] Duenas, Corina, 2017-08-17
[InstanceEdit:9023427] Duenas, Corina, 2017-09-27
[InstanceEdit:9024305] Duenas, Corina, 2017-10-03
[InstanceEdit:9024654] Duenas, Corina, 2017-10-06
[InstanceEdit:9026384] Jupe, Steve, 2017-10-19
[InstanceEdit:9026541] Jupe, Steve, 2017-10-20
textFull-length Interleukin-33 (IL33) binds Caspase- 1, Caspase-3 and Caspase-7 (Luthi et al. 2009).
IL33 is efficiently cleaved at physiological concentrations within apoptotic cells, reducing the proinflammatory activity of IL33 (Lüthi et al. 2009), which may prevent an inappropriate immune response during apoptosis, but not in necrosis.
IL33 has been reported both as a direct substrate of caspase-1 (Cayrol & Gerarld 2009) and to not be a direct caspase-1 substrate (Lüthi et al. 2009) in both cases processing by caspases resulted in IL33 inactivation rather than production of more active shorter forms.
(summation)[BlackBoxEvent:9016628] Unconfirmed and contradicting results - IL33 binds Caspase-3, Caspase-7 [Homo sapiens]
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