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Details on Person UniProt:B4F7B7 Dusp15
| Class:Id | ReferenceGeneProduct:9015741 |
|---|---|
| _chainChangeLog | initiator methionine:1 for 9015741 removed on Fri Nov 03 2023;initiator methionine: for 9015741 added on Fri Nov 03 2023;initiator methionine: for 9015741 removed on Fri Aug 15 2025;initiator methionine:1 for 9015741 added on Fri Aug 15 2025 |
| _displayName | UniProt:B4F7B7 Dusp15 |
| _timestamp | 2025-08-15 21:52:28 |
| chain | initiator methionine:1 chain:2-236 |
| checksum | 005CBEA2E68D64D1 |
| comment | FUNCTION May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (PubMed:27532821). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578). May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateSUBCELLULAR LOCATION Expression increases during oligodendrocyte differentiation.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. |
| created | [InstanceEdit:9015733] Weiser, JD |
| description | recommendedName: fullName evidence="1"Dual specificity protein phosphatase 15 ecNumber evidence="1 3"3.1.3.16 ecNumber evidence="1 3"3.1.3.48 |
| geneName | Dusp15 |
| identifier | B4F7B7 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Hydrolase Lipoprotein Membrane Myristate Protein phosphatase Reference proteome |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Dusp15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DUS15_RAT |
| sequenceLength | 236 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:B4F7B7 Dusp15 (9015741)
