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Details on Person UniProt:A1Z7A6 Asap
| Class:Id | ReferenceGeneProduct:9015734 |
|---|---|
| _displayName | UniProt:A1Z7A6 Asap |
| _timestamp | 2023-11-03 18:21:39 |
| chain | chain:1-1155 |
| checksum | FC4C4832E2C0AFE8 |
| comment | FUNCTION Probable GTPase-activating protein (GAP) for Arf family proteins (Probable). Involved in Golgi apparatus organization by targeting Arf1 to the Golgi, which may be important for membrane trafficking during epithelial morphogenesis (PubMed:27535433). Regulates the positioning of interommatidial precursor cells during compound eye morphogenesis together with Arf6 and Cindr (PubMed:21976699). Required for cleavage furrow ingression in early embryonic cells (PubMed:27535433).SUBUNIT Interacts with Cindr.SUBCELLULAR LOCATION Detected in large puncta at the plasma membrane (PubMed:21976699, PubMed:27535433). Excluded from the nucleus at interphase (PubMed:27535433). Enriched in the nucleus at prometaphase (PubMed:27535433).ALTERNATIVE PRODUCTS Expressed in the ectoderm of embryos (at protein level).DISRUPTION PHENOTYPE RNAi-mediated knockdown results in defective compound eye morphogenesis (PubMed:21976699). Maternal RNAi-mediated knockdown results in partial female infertility and, in early embryos, abnormal aggregation of Golgi apparatus and disrupted cleavage furrow ingression (PubMed:27535433).SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:9015733] Weiser, JD |
| description | recommendedName: fullName evidence="8"ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein |
| geneName | Asap Asap1 CG30372 |
| identifier | A1Z7A6 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ANK repeat Cell membrane Cell projection Cytoplasm Developmental protein GTPase activation Membrane Metal-binding Nucleus Reference proteome Repeat SH3 domain Zinc Zinc-finger |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Asap |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ASAP_DROME E1JH06 Q6AWJ6 Q95R80 |
| sequenceLength | 1155 |
| species | [Species:56210] Drosophila melanogaster |
| (isoformParent) | [ReferenceIsoform:9015735] UniProt:A1Z7A6-1 Asap [Drosophila melanogaster] [ReferenceIsoform:9015736] UniProt:A1Z7A6-2 Asap [Drosophila melanogaster] |
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No pathways have been reviewed or authored by UniProt:A1Z7A6 Asap (9015734)
