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Details on Person HRSP12 deaminates 2-iminobutanoate to 2OBUTA

Class:IdReaction:9014641
_displayNameHRSP12 deaminates 2-iminobutanoate to 2OBUTA
_doReleaseTRUE
_timestamp2025-02-25 22:16:53
authored[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
catalystActivity[CatalystActivity:9014617] 2-iminobutanoate deaminase activity of HRSP12 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
crossReference[DatabaseIdentifier:9929609] RHEA:39976
edited[InstanceEdit:9014640] Jassal, Bijay, 2017-08-02
input[SimpleEntity:9929622] 2-iminobutanoate [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimericFALSE
literatureReference[LiteratureReference:9014628] Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions
[LiteratureReference:9014629] RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life
[LiteratureReference:9014624] Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family
[LiteratureReference:9034683] Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents
[LiteratureReference:9014639] From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species
modified[InstanceEdit:9014731] Jassal, Bijay, 2017-08-03
[InstanceEdit:9017155] Jassal, Bijay, 2017-08-17
[InstanceEdit:9034687] Jassal, Bijay, 2018-01-10
[InstanceEdit:9038494] Jassal, Bijay, 2018-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929610] D'Eustachio, Peter, 2024-11-26
[InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06
[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
nameHRSP12 deaminates 2-iminobutanoate to 2OBUTA
2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)
output[SimpleEntity:936714] 2OBUTA [cytosol]
[SimpleEntity:31633] NH4+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2018-03-21
reviewed[InstanceEdit:9038492] Downs, Diana, 2018-02-28
[InstanceEdit:9038495] Cooper, Arthur, 2018-02-28
[InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9014646] R-HSA-9014641.3
structureModified[InstanceEdit:9929610] D'Eustachio, Peter, 2024-11-26
summation[Summation:9014644] The toxic enamine/imine intermediates generated by pyridoxal...
(hasEvent)[Pathway:8849175] Threonine catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9939820] Update Tracker - [Reaction:9014641] HRSP12 deaminates 2-iminobutanoate to 2OBUTA - v92:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
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