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Details on Person GDIs block activation of RHOG

Class:Id	Reaction:9014456
_displayName	GDIs block activation of RHOG
_doRelease	TRUE
_timestamp	2021-02-25 16:31:02
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9014450] Orlic-Milacic, Marija, 2017-07-28
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
input	[Complex:9014438] RHOG:GDP [plasma membrane] [Homo sapiens] [DefinedSet:9014455] ARHGDIA,ARHGDIB,ARHGDIG [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9681571] RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG [LiteratureReference:9692961] RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain [LiteratureReference:9692962] Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway [LiteratureReference:5625953] Kinectin is a key effector of RhoG microtubule-dependent cellular activity
modified	[InstanceEdit:9692963] Orlic-Milacic, Marija, 2020-06-27 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714747] Orlic-Milacic, Marija, 2021-02-14 [InstanceEdit:9714838] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GDIs block activation of RHOG
output	[Complex:9014453] RHOG GDIs:RHOG:GDP [cytosol] [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014461] R-HSA-9014456.2
summation	[Summation:9692957] The following GDP dissociation inhibitors (GDIs) bind to RHO...
(hasEvent)	[Pathway:9013408] RHOG GTPase cycle [Homo sapiens]
(replacementInstances)	[_Deleted:9768324] Deletion of instance: 194854
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No pathways have been reviewed or authored by GDIs block activation of RHOG (9014456)