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Details on Person IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex

Class:Id	Reaction:9014343
_displayName	IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
_doRelease	TRUE
_timestamp	2017-12-01 23:34:29
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9014345] Shamovsky, Veronica, 2017-07-28
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens] [Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:451569] Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] [LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
modified	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex Nemo subunit of IKK complex binds polyubiquinated RIP1
output	[Complex:9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [Homo sapiens] [Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014346] R-HSA-9014343.3
summation	[Summation:940405] Structural studies showed that NEMO binds both Lys-63- and l...
(hasEvent)	[Pathway:168927] TICAM1, RIP1-mediated IKK complex recruitment [Homo sapiens]
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No pathways have been reviewed or authored by IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (9014343)