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Details on Person K63-linked ubiquitination of RIP1 bound to the activated TLR complex

Class:Id	Reaction:9014342
_displayName	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
_doRelease	TRUE
_timestamp	2017-12-01 23:34:47
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:2569080] ubiquitin-protein transferase activity of RIP1 ubiqutin ligases [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9014345] Shamovsky, Veronica, 2017-07-28
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Complex:177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO [LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B [LiteratureReference:2569072] cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
modified	[InstanceEdit:9014566] Shamovsky, Veronica, 2017-08-01 [InstanceEdit:9014659] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
output	[Complex:9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 [Homo sapiens] [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014348] R-HSA-9014342.3
summation	[Summation:939839] RIP1 polyubiquitination was induced upon TNF- or poly(I-C) t...
(hasEvent)	[Pathway:168927] TICAM1, RIP1-mediated IKK complex recruitment [Homo sapiens]
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