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Details on Person SARM (sterile alpha-and armadillo-motif-containing protein) ...
| Class:Id | Summation:9014321 |
|---|---|
| _displayName | SARM (sterile alpha-and armadillo-motif-containing protein) ... |
| _timestamp | 2017-07-28 03:05:05 |
| created | [InstanceEdit:9014319] Shamovsky, Veronica, 2017-07-28 |
| literatureReference | [LiteratureReference:2559574] The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling [LiteratureReference:9013861] SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions |
| text | SARM (sterile alpha-and armadillo-motif-containing protein) is a TIR-domain-containing adaptor, which functions as a negative regulator of TRIF (TICAM1)-dependent Toll-like receptor signaling in humans. A pairwise yeast two-hybrid assay demonstrated that SARM is capable of binding directly to TICAM1 (Carty M et al. 2006). GST pulldown studies suggest that protein-protein interactions occur between the TIR domains of SARM and TICAM1 (Carlsson E et al. 2016). The complex of TICAM1:SARM is thought to inhibit downstream TRIF signaling by preventing the recruitment of TRIF effector proteins (Carty M et al. 2006). SARM expression was shown to inhibit poly(I:C)-induced TICAM1-dependent NFkappaB activaion, RANTES production and IRF activation in human embryonic kidney HEK293 cells (Carty M et al. 2006). Moreover, suppression of endogenous SARM expression by siRNA led to enhanced TLR3- and TLR4-dependent gene induction in both transformed HEK293 and primary PBMC cells (Carty M et al. 2006), Thus, SARM associates with TICAM1 via its TIR and sterile-alpha motif (SAM) domains to block the induction of proinflammatory genes downstream TLR3. |
| (summation) | [Reaction:9014320] SARM binds viral dsRNA:TLR3:TICAM1 [Homo sapiens] |
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