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Details on Person RAC2 GEFs activate RAC2

Class:Id	Reaction:9014296
_displayName	RAC2 GEFs activate RAC2
_doRelease	TRUE
_timestamp	2021-02-25 16:31:33
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
catalystActivity	[CatalystActivity:9014402] guanyl-nucleotide exchange factor activity of RAC2 GEFs [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9014292] Orlic-Milacic, Marija, 2017-07-27
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
input	[Complex:9014401] RAC2:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8980785] Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family [LiteratureReference:9644596] Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis [LiteratureReference:9644586] Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors [LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:9644614] P-Rex1 regulates neutrophil function [LiteratureReference:9644542] P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils [LiteratureReference:9644594] Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase [LiteratureReference:9644576] Comparative functional analysis of the Rac GTPases [LiteratureReference:9644617] RNA-aptamers that modulate the RhoGEF activity of Tiam1 [LiteratureReference:9644599] Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila [LiteratureReference:9644602] Rac function and regulation during Drosophila development [LiteratureReference:9644628] The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells [LiteratureReference:9644627] The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity [LiteratureReference:9644647] Vav proteins control MyD88-dependent oxidative burst [LiteratureReference:9644646] Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation [LiteratureReference:9644623] The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis [LiteratureReference:9644363] Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells [LiteratureReference:9691545] SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration [LiteratureReference:9644214] Asef is a Cdc42-specific guanine nucleotide exchange factor [LiteratureReference:8980827] The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3 [LiteratureReference:9691488] DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA
modified	[InstanceEdit:9014406] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9644582] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644622] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644653] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9644654] Orlic-Milacic, Marija, 2019-04-15 [InstanceEdit:9691548] Orlic-Milacic, Marija, 2020-06-17 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714229] Orlic-Milacic, Marija, 2021-02-09 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716676] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAC2 GEFs activate RAC2
output	[Complex:9014399] RAC2:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014300] R-HSA-9014296.2
summation	[Summation:9644581] The following guanine nucleotide exchange factors (GEFs) wer...
(hasEvent)	[Pathway:9013404] RAC2 GTPase cycle [Homo sapiens]
(precedingEvent)	[Reaction:9014294] RAC2 binds effectors at the plasma membrane [Homo sapiens] [Reaction:9014295] RAC2 GAPs stimulate RAC2 GTPase activity [Homo sapiens] [BlackBoxEvent:9014420] RAC2 translocates to the phagocytic vesicle membrane [Homo sapiens] [BlackBoxEvent:9714480] RAC2 translocates to the mitochondrial membrane [Homo sapiens] [BlackBoxEvent:9714483] RAC2 translocates to the ER membrane [Homo sapiens]
(replacementInstances)	[_Deleted:9768327] Deletion of instance: 194913
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No pathways have been reviewed or authored by RAC2 GEFs activate RAC2 (9014296)