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Details on Person RAC2 binds effectors at the plasma membrane

Class:Id	Reaction:9014294
_displayName	RAC2 binds effectors at the plasma membrane
_doRelease	TRUE
_timestamp	2021-02-25 16:31:43
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9014292] Orlic-Milacic, Marija, 2017-07-27
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
input	[Complex:9014399] RAC2:GTP [plasma membrane] [Homo sapiens] [CandidateSet:9014425] RAC2 plasma membrane effectors [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:437152] Rac GTPase interacts specifically with phosphatidylinositol 3-kinase [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9691732] Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion [LiteratureReference:9691733] Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways [LiteratureReference:2028786] Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis [LiteratureReference:442644] Structural requirements for PAK activation by Rac GTPases [LiteratureReference:9691785] Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4 [LiteratureReference:5668616] Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways [LiteratureReference:5668623] Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 [LiteratureReference:9694104] Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2
modified	[InstanceEdit:9014431] Orlic-Milacic, Marija, 2017-07-28 [InstanceEdit:9691587] Orlic-Milacic, Marija, 2020-06-17 [InstanceEdit:9691741] Orlic-Milacic, Marija, 2020-06-18 [InstanceEdit:9691796] Orlic-Milacic, Marija, 2020-06-19 [InstanceEdit:9691801] Orlic-Milacic, Marija, 2020-06-19 [InstanceEdit:9694018] Orlic-Milacic, Marija, 2020-07-08 [InstanceEdit:9694106] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714229] Orlic-Milacic, Marija, 2021-02-09 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716674] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAC2 binds effectors at the plasma membrane
output	[Complex:9014423] RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9014296] RAC2 GEFs activate RAC2 [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014299] R-HSA-9014294.2
summation	[Summation:9691787] In its GTP bound active form, plasma membrane associated RAC...
(hasEvent)	[Pathway:9013404] RAC2 GTPase cycle [Homo sapiens]
(replacementInstances)	[_Deleted:9716816] Deletion of instance: 194894
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No pathways have been reviewed or authored by RAC2 binds effectors at the plasma membrane (9014294)