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Details on Person K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane]

Class:Id	Complex:9013989
_displayName	K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane]
_timestamp	2017-12-01 23:52:16
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
hasComponent	[EntityWithAccessionedSequence:936402] K63polyUb-TRAF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936402] K63polyUb-TRAF3 [cytosol] [Homo sapiens] [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens] [Complex:167985] viral dsRNA :TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [DefinedSet:9038432] TLR3 ligand [endosome lumen] [Hepatitis B virus] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
modified	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	K63polyUb-TRAF3:TICAM1:activated TLR3 K63polyUb-TRAF3:TRIF:activated TLR3
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013999] R-HSA-9013989.2
(hasComponent)	[Complex:9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [Homo sapiens] [Complex:9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] [Homo sapiens]
(input)	[Reaction:9013985] TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 [Homo sapiens]
(output)	[BlackBoxEvent:9013974] Auto-ubiquitination of TRAF3 within activated TLR3 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9898415] Update Tracker - [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] - v63:[updateContainedComponent] [_UpdateTracker:9898962] Update Tracker - [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] - v64:[updateContainedComponent]
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No pathways have been reviewed or authored by K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (9013989)