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Details on Person TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3

Class:Id	Reaction:9013985
_displayName	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
_doRelease	TRUE
_timestamp	2017-12-01 23:36:34
authored	[InstanceEdit:5475178] Shamovsky, V, 2014-05-16
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input	[EntityWithAccessionedSequence:933407] TANK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933407] TANK [cytosol] [Homo sapiens] [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:933515] Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
modified	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
output	[Complex:9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9013974] Auto-ubiquitination of TRAF3 within activated TLR3 complex [Homo sapiens] [Reaction:9013992] TRAF3 binds to TRIF:activated TLR3 complex [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2014-06-10
reviewed	[InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013996] R-HSA-9013985.3
summation	[Summation:9013994] TRAF family member-associated NFkB activator (TANK or ITRAF...
(hasEvent)	[Pathway:9013973] TICAM1-dependent activation of IRF3/IRF7 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9013990] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA [Homo sapiens]
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No pathways have been reviewed or authored by TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (9013985)