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Details on Person activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

Class:IdComplex:9013982
_displayNameactivated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]
_timestamp2023-01-12 00:03:11
compartment[Compartment:74700] endosome membrane
created[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
[LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
[LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
modified[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9823889] Shamovsky, Veronica, 2023-01-11
[InstanceEdit:9823897] Shamovsky, Veronica, 2023-01-12
nameactivated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE
relatedSpecies[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9013998] R-HSA-9013982.3
(hasComponent)[Complex:9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] [Homo sapiens]
(input)[Reaction:9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 [Homo sapiens]
(output)[Reaction:9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9898368] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v63:[updateContainedComponent]
[_UpdateTracker:9899067] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v64:[updateContainedComponent]
[_UpdateTracker:9901835] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v75:[updateContainedComponent]
[_UpdateTracker:9904002] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v80:[updateContainedComponent]
[_UpdateTracker:9904751] Update Tracker - [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - v84:[add_removeHasComponent, modifyName]
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No pathways have been reviewed or authored by activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (9013982)
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