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Details on Person Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex

Class:Id	Reaction:9013978
_displayName	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
_doRelease	TRUE
_timestamp	2017-12-01 23:35:14
authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:9013988] protein serine/threonine kinase activity of activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical
modified	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens] [Complex:9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 [Homo sapiens] [Reaction:9830706] IKKε (IKBKE) is phosphorylated within the activated TLR3 complex [Homo sapiens] [Reaction:9828205] TBK1 is phosphorylated within the activated TLR3 complex [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9014002] R-HSA-9013978.3
summation	[Summation:9013977] Human IRF3 is activated through a two step phosphorylation i...
(hasEvent)	[Pathway:9013973] TICAM1-dependent activation of IRF3/IRF7 [Homo sapiens]
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