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Details on Person Caspase-8 processing within TLR3 complex

Class:Id	Reaction:9013895
_displayName	Caspase-8 processing within TLR3 complex
_doRelease	TRUE
_timestamp	2017-12-01 23:34:08
authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
catalystActivity	[CatalystActivity:9013890] cysteine-type endopeptidase activity of activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013896] Shamovsky, Veronica, 2017-07-26
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
input	[Complex:9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2562571] dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8 [LiteratureReference:1267800] Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:1267836] Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation [LiteratureReference:2584573] Insights into the regulatory mechanism for caspase-8 activation
modified	[InstanceEdit:9014331] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-8 processing within TLR3 complex
output	[Complex:2562550] active caspase-8 [cytosol] [Homo sapiens] [Complex:9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9013889] TLR3-induced ripoptosome assembly [Homo sapiens] [Reaction:168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2012-12-04
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013899] R-HSA-9013895.3
summation	[Summation:9013892] TLR3 and TLR4 were shown to mediate apoptosis in various hum...
(hasEvent)	[Pathway:9013957] TLR3-mediated TICAM1-dependent programmed cell death [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9757951] CASP8 cleaves N4BP1 at D424, D490 [Homo sapiens]
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