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Details on Person IFI16 ligands [cytosol]

Class:Id	DefinedSet:9013802
_displayName	IFI16 ligands [cytosol]
_timestamp	2017-07-26 05:30:48
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9013808] Shamovsky, Veronica, 2017-07-26
disease	[Disease:3134794] viral infectious disease [Disease:3134792] bacterial infectious disease
goCellularComponent	[Compartment:436407] host cell cytosol
hasMember	[GenomeEncodedEntity:9013755] VACV dsDNA [cytosol] [Vaccinia virus] [Complex:177535] viral DNA with 3' sticky ends [cytosol] [Human immunodeficiency virus 1] [GenomeEncodedEntity:8982066] HSV1 dsDNA [cytosol] [Human herpesvirus 1] [GenomeEncodedEntity:8982051] L. monocytogenes dsDNA [cytosol] [Listeria monocytogenes]
literatureReference	[LiteratureReference:9013779] IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication [LiteratureReference:9013782] Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors [LiteratureReference:8982056] Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway [LiteratureReference:9013804] IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
modified	[InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	IFI16 ligands
species	[Species:164493] Human immunodeficiency virus 1 [Species:2671785] Vaccinia virus [Species:5689680] Human herpesvirus 1 [Species:8875362] Listeria monocytogenes
stableIdentifier	[StableIdentifier:9013812] R-NUL-9013802.19
(hasComponent)	[Complex:1834947] dsDNA:IFI16 [cytosol] [Homo sapiens]
(input)	[Reaction:1834951] IFI16 binds cytosolic dsDNA [Homo sapiens]
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No pathways have been reviewed or authored by IFI16 ligands [cytosol] (9013802)