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Details on Person CDC42 GDIs block activation of CDC42

Class:Id	Reaction:9013158
_displayName	CDC42 GDIs block activation of CDC42
_doRelease	TRUE
_timestamp	2021-06-11 00:17:21
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013160] Orlic-Milacic, Marija, 2017-07-24
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
input	[Complex:9013230] CDC42:GDP [plasma membrane] [Homo sapiens] [DefinedSet:9013243] CDC42 GDIs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9681554] ARHGDIA: a novel gene implicated in nephrotic syndrome [LiteratureReference:9690973] Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I [LiteratureReference:196633] RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas [LiteratureReference:9692768] Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells [LiteratureReference:9692765] Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways
modified	[InstanceEdit:9013167] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013248] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9026093] Orlic-Milacic, Marija, 2017-10-17 [InstanceEdit:9028492] Orlic-Milacic, Marija, 2017-11-08 [InstanceEdit:9692640] Orlic-Milacic, Marija, 2020-06-24 [InstanceEdit:9692772] Orlic-Milacic, Marija, 2020-06-25 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9705972] Orlic-Milacic, Marija, 2020-11-03 [InstanceEdit:9714845] Orlic-Milacic, Marija, 2021-02-15 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733841] Orlic-Milacic, Marija, 2021-06-10 [InstanceEdit:9733843] Orlic-Milacic, Marija, 2021-06-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDC42 GDIs block activation of CDC42
output	[Complex:9013239] CDC42:GDP:CDC42 GDIs [cytosol] [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013162] R-HSA-9013158.3
summation	[Summation:9692638] The following GDP dissociation inhibitors (GDIs) bind to CDC...
(hasEvent)	[Pathway:9013148] CDC42 GTPase cycle [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
(replacementInstances)	[_Deleted:9768324] Deletion of instance: 194854
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No pathways have been reviewed or authored by CDC42 GDIs block activation of CDC42 (9013158)