Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RAC1 binds effectors at the plasma membrane

Class:Id	Reaction:9013145
_displayName	RAC1 binds effectors at the plasma membrane
_doRelease	TRUE
_timestamp	2024-02-22 21:28:45
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013146] Orlic-Milacic, Marija, 2017-07-24
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9861985] Orlic-Milacic, Marija, 2024-02-21
input	[Complex:442641] RAC1:GTP [plasma membrane] [Homo sapiens] [CandidateSet:9013178] RAC1 effectors [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:442649] A brain serine/threonine protein kinase activated by Cdc42 and Rac1 [LiteratureReference:5628821] Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family [LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1 [LiteratureReference:5668717] Nox1-dependent reactive oxygen generation is regulated by Rac1 [LiteratureReference:5668610] Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism [LiteratureReference:5668702] Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1 [LiteratureReference:5668733] Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases [LiteratureReference:5668740] Role of the small GTPase Rac in p22phox-dependent NADPH oxidases [LiteratureReference:5626508] Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 [LiteratureReference:5626488] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth [LiteratureReference:5626515] The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration [LiteratureReference:5626534] The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases [LiteratureReference:9691002] Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2 [LiteratureReference:437152] Rac GTPase interacts specifically with phosphatidylinositol 3-kinase [LiteratureReference:437149] Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB [LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages [LiteratureReference:5625892] A novel partner for the GTP-bound forms of rho and rac [LiteratureReference:5625916] Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron [LiteratureReference:5624312] Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1) [LiteratureReference:5624309] The Rac1 polybasic region is required for interaction with its effector PRK1 [LiteratureReference:5624305] Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9691198] PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia [LiteratureReference:9691229] ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells [LiteratureReference:9691235] Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway [LiteratureReference:9691400] The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins [LiteratureReference:9691401] Serine-71 phosphorylation of Rac1 modulates downstream signaling [LiteratureReference:9691399] Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin [LiteratureReference:2028953] WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac [LiteratureReference:2028955] Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac [LiteratureReference:5666179] Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain [LiteratureReference:5627666] The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton [LiteratureReference:5666071] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets [LiteratureReference:5665731] FMNL2 drives actin-based protrusion and migration downstream of Cdc42 [LiteratureReference:9692502] PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells [LiteratureReference:9692634] Molecular cloning and characterization of a novel human STE20-like kinase, hSLK [LiteratureReference:9692908] A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation [LiteratureReference:9694089] AR and ER interaction with a p21-activated kinase (PAK6) [LiteratureReference:9694049] Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha [LiteratureReference:442588] Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome [LiteratureReference:9694096] Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32 [LiteratureReference:9861981] Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent
modified	[InstanceEdit:9013167] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013187] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9020699] Rothfels, Karen, 2017-09-11 [InstanceEdit:9020720] Rothfels, Karen, 2017-09-11 [InstanceEdit:9690981] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9690998] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9690999] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691003] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691147] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691157] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691158] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691171] Orlic-Milacic, Marija, 2020-06-08 [InstanceEdit:9691203] Orlic-Milacic, Marija, 2020-06-09 [InstanceEdit:9691232] Orlic-Milacic, Marija, 2020-06-10 [InstanceEdit:9691238] Orlic-Milacic, Marija, 2020-06-10 [InstanceEdit:9691380] Orlic-Milacic, Marija, 2020-06-13 [InstanceEdit:9691404] Orlic-Milacic, Marija, 2020-06-13 [InstanceEdit:9691407] Orlic-Milacic, Marija, 2020-06-15 [InstanceEdit:9692508] Orlic-Milacic, Marija, 2020-06-24 [InstanceEdit:9692636] Orlic-Milacic, Marija, 2020-06-24 [InstanceEdit:9692911] Orlic-Milacic, Marija, 2020-06-26 [InstanceEdit:9694018] Orlic-Milacic, Marija, 2020-07-08 [InstanceEdit:9694091] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9694099] Orlic-Milacic, Marija, 2020-07-10 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714464] Orlic-Milacic, Marija, 2021-02-11 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861984] Orlic-Milacic, Marija, 2024-02-21 [InstanceEdit:9862097] Orlic-Milacic, Marija, 2024-02-22
name	RAC1 binds effectors at the plasma membrane
output	[Complex:9013182] RAC1:GTP:RAC1 effectors [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9013143] RAC1 GEFs activate RAC1 [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013152] R-HSA-9013145.3
summation	[Summation:9691378] In its GTP bound active form, plasma membrane associated RAC...
(hasEvent)	[Pathway:9013149] RAC1 GTPase cycle [Homo sapiens]
(replacementInstances)	[_Deleted:9716816] Deletion of instance: 194894
(updatedInstance)	[_UpdateTracker:9864151] Update Tracker - [Reaction:9013145] RAC1 binds effectors at the plasma membrane - v88:[add_removeLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by RAC1 binds effectors at the plasma membrane (9013145)