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Details on Person Ubiquitination of DLL/JAG ligands upon binding to NOTCH3

Class:Id	Reaction:9013069
_displayName	Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
_doRelease	TRUE
_timestamp	2017-11-02 15:24:30
authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
catalystActivity	[CatalystActivity:1980072] ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9013070] Orlic-Milacic, Marija, 2017-07-21
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
entityOnOtherCell	[CandidateSet:1911464] MIB/NEURL [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:157643] DLL/JAG [plasma membrane] [Homo sapiens]
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
inferredFrom	[Reaction:209226] DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) [Drosophila melanogaster]
input	[DefinedSet:9013071] DLL/JAG:NOTCH3 [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9013075] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013100] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9013105] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9024182] Orlic-Milacic, Marija, 2017-10-02 [InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
output	[DefinedSet:9013089] Ub-DLL/JAG:NOTCH3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:157145] NOTCH3 binds DLL1 [Homo sapiens] [BlackBoxEvent:1912382] Mature NOTCH heterodimer traffics to the plasma membrane [Homo sapiens] [Reaction:157100] NOTCH3 binds JAG1 [Homo sapiens] [Reaction:157124] NOTCH3 binds JAG2 [Homo sapiens] [Reaction:2168136] NOTCH3 binds DLL4 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013073] R-HSA-9013069.2
summation	[Summation:9013103] Based on an analogy with NOTCH1 and NOTCH2, and on studies o...
(hasEvent)	[Pathway:9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)	[Reaction:9013284] NOTCH3-ligand complex is cleaved to produce NEXT3 [Homo sapiens]
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