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Details on Person RHOB GAPs stimulate RHOB GTPase activity

Class:Id	Reaction:9013022
_displayName	RHOB GAPs stimulate RHOB GTPase activity
_doRelease	TRUE
_timestamp	2021-02-25 16:32:24
authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9013041] GTPase activator activity of RHOB GAPs [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9013025] Orlic-Milacic, Marija, 2017-07-21
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
input	[Complex:8981459] RHOB:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9679693] DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms [LiteratureReference:9679631] Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS [LiteratureReference:8985695] Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri [LiteratureReference:9679680] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis [LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9690482] The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking
modified	[InstanceEdit:9013043] Orlic-Milacic, Marija, 2017-07-21 [InstanceEdit:9026093] Orlic-Milacic, Marija, 2017-10-17 [InstanceEdit:9028492] Orlic-Milacic, Marija, 2017-11-08 [InstanceEdit:9690457] Orlic-Milacic, Marija, 2020-06-01 [InstanceEdit:9690483] Orlic-Milacic, Marija, 2020-06-01 [InstanceEdit:9696553] Orlic-Milacic, Marija, 2020-07-22 [InstanceEdit:9697611] Orlic-Milacic, Marija, 2020-08-18 [InstanceEdit:9698215] Orlic-Milacic, Marija, 2020-08-24 [InstanceEdit:9714274] Orlic-Milacic, Marija, 2021-02-10 [InstanceEdit:9715101] Orlic-Milacic, Marija, 2021-02-16 [InstanceEdit:9715390] Orlic-Milacic, Marija, 2021-02-17 [InstanceEdit:9716668] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716676] Orlic-Milacic, Marija, 2021-02-23 [InstanceEdit:9716799] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RHOB GAPs stimulate RHOB GTPase activity
output	[Complex:8985690] RHOB:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9013023] RHOB GEFs activate RHOB [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9013031] R-HSA-9013022.2
summation	[Summation:9690481] The following GTPase activating proteins (GAPs) were shown t...
(hasEvent)	[Pathway:9013026] RHOB GTPase cycle [Homo sapiens] [Pathway:9025112] (NEW)ROCK signaling regulates MRLC phosphorylation [Homo sapiens]
(replacementInstances)	[_Deleted:9768323] Deletion of instance: 194922
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No pathways have been reviewed or authored by RHOB GAPs stimulate RHOB GTPase activity (9013022)