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Details on Person Interleukin-18 (IL18) in its biologically active form (IL18 ...

Class:IdSummation:9012699
_displayNameInterleukin-18 (IL18) in its biologically active form (IL18 ...
_timestamp2017-10-20 15:27:00
created[InstanceEdit:9012687] Duenas, Corina, 2017-07-18
literatureReference[LiteratureReference:449049] Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
[LiteratureReference:9024284] Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
[LiteratureReference:449064] Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
modified[InstanceEdit:9012786] Duenas, Corina, 2017-07-19
[InstanceEdit:9012807] Duenas, Corina, 2017-07-19
[InstanceEdit:9013296] Duenas, Corina, 2017-07-24
[InstanceEdit:9013348] Duenas, Corina, 2017-07-24
[InstanceEdit:9022964] Duenas, Corina, 2017-09-26
[InstanceEdit:9024301] Duenas, Corina, 2017-10-03
[InstanceEdit:9026564] Jupe, Steve, 2017-10-20
textInterleukin-18 (IL18) in its biologically active form (IL18 residues 37-193) and the propeptide fragment of IL18 (residues 1-36) dissociate from the Caspase-1 tetrameric complex (Ghayur et al. 1997, Akita et al. 1997, Gu et al. 1997). This is a black box event because dissociation is implied from the subsequent secretion of IL18.
(summation)[BlackBoxEvent:9012092] IL18 and IL18 propeptide dissociate from Caspase-1 tetramer [Homo sapiens]
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