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Details on Person Interleukin-7 (IL7) up-regulates Cytokine-inducible SH2-cont...
| Class:Id | Summation:9012669 |
|---|---|
| _displayName | Interleukin-7 (IL7) up-regulates Cytokine-inducible SH2-cont... |
| _timestamp | 2017-09-22 14:18:30 |
| created | [InstanceEdit:9012672] Duenas, Corina, 2017-07-17 |
| literatureReference | [LiteratureReference:8982812] Suppressor of cytokine signaling (SOCS) proteins are induced by IL-7 and target surface CD127 protein for degradation in human CD8 T cells [LiteratureReference:508000] An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein [LiteratureReference:507994] DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites [LiteratureReference:1364049] GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism [LiteratureReference:982766] In vivo analysis of growth hormone receptor signaling domains and their associated transcripts [LiteratureReference:508024] Information networks in the mammary gland [LiteratureReference:1364061] Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis |
| modified | [InstanceEdit:9021134] Duenas, Corina, 2017-09-14 [InstanceEdit:9021931] Duenas, Corina, 2017-09-21 [InstanceEdit:9022293] Duenas, Corina, 2017-09-22 |
| text | Interleukin-7 (IL7) up-regulates Cytokine-inducible SH2-containing protein (CISH), Suppressor of cytokine signaling 1(SOCS1), Suppressor of cytokine signaling 2(SOCS2) and Suppressor of cytokine signaling 3 (SOCS3) mRNA transcripts in primary human CD8 T cells. IL7 induces CISH and SOCS1-3 transcripts via the JAK/STAT5 signaling pathway (Ghazawi et al. 2016). Signal transducer and activator of transcription 5A (STAT5A) and Signal transducer and activator of transcription 5B (STAT5B) dimers bind to similar core gamma-interferon activated sequence (GAS) motifs (Soldaini et al., 2000). STAT5 also form homo- and hetero-tetramers with distinct or expanded DNA-binding properties. This is a black box event because apart of the mentioned here genes could be another subset of genes up or downregulated by STAT5. Genes that are regulated by STAT5 include Interleukin-2 receptor alpha (IL2RA) (John et al. 1996), TNFSF11 (RANKL), Connexin-26 (GJB2) and Cyclin D1 (Hennighausen & Robinson, 2005). A comprehensive listing of hepatic STAT5B regulated genes is available from microarray/STAT5B knockout mice (Clodfelter et al. 2006), and similarly for STAT5-dependent genes regulated by the GH receptor (Rowland et al. 2005, Barclay et al. 2011). |
| (summation) | [BlackBoxEvent:9012671] p-STAT5 binds CISH, SOCS1 and SOCS2 gene [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-7 (IL7) up-regulates Cytokine-inducible SH2-cont... (9012669)
