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Details on Person JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2

Class:Id	Reaction:9012650
_displayName	JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
_doRelease	TRUE
_timestamp	2018-08-14 15:54:28
authored	[InstanceEdit:9009422] May, Bruce, 2017-06-17
catalystActivity	[CatalystActivity:9012659] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9012655] May, Bruce, 2017-07-17
edited	[InstanceEdit:9009422] May, Bruce, 2017-06-17
inferredFrom	[Reaction:9012653] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5 [Mus musculus]
input	[Complex:9012638] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9027092] Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity [LiteratureReference:9027097] Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells [LiteratureReference:9027168] Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome [LiteratureReference:9027128] Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors [LiteratureReference:9027176] Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7 [LiteratureReference:9027122] A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation [LiteratureReference:9027120] Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5 [LiteratureReference:9027192] Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: transient versus sustained proliferation
modified	[InstanceEdit:9027297] May, Bruce, 2017-10-29 [InstanceEdit:9030341] May, Bruce, 2017-11-27 [InstanceEdit:9616794] Matthews, Lisa, 2018-08-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
output	[Complex:9012641] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-STAT5 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9012654] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 [Homo sapiens] [Reaction:9006323] Phospho-JAK2 phosphorylates EPOR [Homo sapiens]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9012664] R-HSA-9012650.2
summation	[Summation:9030311] After STAT5 binds the EPO:EPOR complex, phosphorylated JAK2 ...
(hasEvent)	[Pathway:9027283] Erythropoietin activates STAT5 [Homo sapiens]
(precedingEvent)	[Reaction:9012651] p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 [Homo sapiens]
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No pathways have been reviewed or authored by JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (9012650)