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Details on Person IL37 binds 2x(CASP1(120-197):CASP1(317-404))

Class:Id	BlackBoxEvent:9012542
_displayName	IL37 binds 2x(CASP1(120-197):CASP1(317-404))
_doRelease	TRUE
_timestamp	2017-11-10 11:04:15
authored	[InstanceEdit:9026226] Duenas, Corina, 2017-10-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9012549] Duenas, Corina, 2017-07-17
edited	[InstanceEdit:9023343] Varusai, Thawfeek, 2017-09-27
input	[EntityWithAccessionedSequence:9008596] IL37 [cytosol] [Homo sapiens] [Complex:448691] Caspase-1 tetramer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8848516] Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production [LiteratureReference:9008582] IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp [LiteratureReference:9008686] Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses [LiteratureReference:9008566] The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines
modified	[InstanceEdit:9012702] Duenas, Corina, 2017-07-18 [InstanceEdit:9012846] Duenas, Corina, 2017-07-20 [InstanceEdit:9012869] Duenas, Corina, 2017-07-20 [InstanceEdit:9014804] Varusai, Thawfeek, 2017-08-04 [InstanceEdit:9027501] Varusai, Thawfeek, 2017-11-02 [InstanceEdit:9028366] Varusai, Thawfeek, 2017-11-07 [InstanceEdit:9028798] Varusai, Thawfeek, 2017-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL37 binds 2x(CASP1(120-197):CASP1(317-404)) IL-37 binds 2x(CASP1(120-197):CASP1(317-404)) IL-37 binds caspase-1 active tetramer
output	[Complex:9012553] IL37:2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9012092] IL18 and IL18 propeptide dissociate from Caspase-1 tetramer [Homo sapiens] [Reaction:9012499] IL18(1-193) is cleaved by Caspase-1 active tetramer:IL18(1-193) complex [Homo sapiens] [BlackBoxEvent:9012500] IL18-2(1-36) and IL18-2(37-189) dissociates from IL18-2(1-36):IL18-2(37-189):2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] [BlackBoxEvent:9012515] IL18-2:2x(CASP1(120-197):CASP1(317-404)) cleaves IL18-2 [Homo sapiens] [BlackBoxEvent:9012689] IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) [Homo sapiens] [BlackBoxEvent:9012556] IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 [Homo sapiens]
releaseDate	2017-12-13
reviewed	[InstanceEdit:9027502] Carriero, Roberta, 2017-11-02 [InstanceEdit:9027496] Garlanda, Cecilia, 2017-11-02 [InstanceEdit:9027499] Mantovani, Alberto, 2017-11-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9012574] R-HSA-9012542.2
summation	[Summation:9028367] Interleukins (IL) are immunomodulatory proteins that elicit ...
(hasEvent)	[Pathway:9008059] Interleukin-37 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9012556] IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 [Homo sapiens]
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No pathways have been reviewed or authored by IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (9012542)