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Details on Person IL18-2:2x(CASP1(120-197):CASP1(317-404)) cleaves IL18-2

Class:Id	BlackBoxEvent:9012515
_displayName	IL18-2:2x(CASP1(120-197):CASP1(317-404)) cleaves IL18-2
_doRelease	FALSE
_timestamp	2024-07-16 19:49:35
catalystActivity	[CatalystActivity:9012516] endopeptidase activity of IL18-2:2x(CASP1(120-197):CASP1(317-404)) [cytosol]
catalystActivityReference	[CatalystActivityReference:9643056] endopeptidase activity of IL18-2:2x(CASP1(120-197):CASP1(317-404)) [cytosol] Cloning and characterization of a new isoform of mouse interleukin-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9012524] Duenas, Corina, 2017-07-14
input	[Complex:9012506] IL18-2:2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9012513] Cloning and characterization of a new isoform of mouse interleukin-18
modified	[InstanceEdit:9012702] Duenas, Corina, 2017-07-18 [InstanceEdit:9012846] Duenas, Corina, 2017-07-20 [InstanceEdit:9012869] Duenas, Corina, 2017-07-20 [InstanceEdit:9014804] Varusai, Thawfeek, 2017-08-04 [InstanceEdit:9024301] Duenas, Corina, 2017-10-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	IL18-2:2x(CASP1(120-197):CASP1(317-404)) cleaves IL18-2 pre-IL18 alpha isoform is cleaved by Caspase-1 active tetramer:IL18(1-193) complex
output	[Complex:9012502] IL18-2(1-36):IL18-2(37-189):2x(CASP1(120-197):CASP1(317-404)) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9012520] IL18-2 binds 2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] [BlackBoxEvent:9012092] IL18 and IL18 propeptide dissociate from Caspase-1 tetramer [Homo sapiens] [BlackBoxEvent:9012689] IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9012532] R-HSA-9012515.1
summation	[Summation:9012686] Interleukin-18 isoform 2 (IL18-2 or pre-IL18 alpha isoform) ...
(precedingEvent)	[BlackBoxEvent:9012500] IL18-2(1-36) and IL18-2(37-189) dissociates from IL18-2(1-36):IL18-2(37-189):2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens]
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No pathways have been reviewed or authored by IL18-2:2x(CASP1(120-197):CASP1(317-404)) cleaves IL18-2 (9012515)