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Details on Person Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain c...

Class:Id	Summation:9012239
_displayName	Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain c...
_timestamp	2018-07-31 02:20:36
created	[InstanceEdit:9012242] Shamovsky, Veronica, 2017-07-12
literatureReference	[LiteratureReference:8983695] Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease [LiteratureReference:1015638] Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease [LiteratureReference:8985115] Innate immune messenger 2-5A tethers human RNase L into active high-order complexes [LiteratureReference:9009969] Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs [LiteratureReference:9009968] RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting [LiteratureReference:9614477] rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells [LiteratureReference:9614467] 2-5A-dependent RNase molecules dimerize during activation by 2-5A [LiteratureReference:9614480] Ribosomal RNA cleavage, nuclease activation and 2-5A(ppp(A2'p)nA) in interferon-treated cells [LiteratureReference:9614484] A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system [LiteratureReference:9614474] Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L [LiteratureReference:9614468] RNase L triggers autophagy in response to viral infections [LiteratureReference:9614479] Small self-RNA generated by RNase L amplifies antiviral innate immunity [LiteratureReference:9614481] Cell-type-specific effects of RNase L on viral induction of beta interferon
modified	[InstanceEdit:9614887] Shamovsky, Veronica, 2018-07-30 [InstanceEdit:9615060] Shamovsky, Veronica, 2018-07-31
text	Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain containing dual endoribonuclease-pseudokinase which is encoded by RNASEL gene (Wreschner DH et al. 1982; Zhou A et al.1993; Hassel BA et al. 1993; Huang H et al. 2014; Han Y et al. 2014). Activated RNase L forms a homodimer (Dong B & Silverman RH 1995) which cleaves within single-stranded regions of different RNA substrates, predominantly after UpAp and UpUp dinucleotides, leaving 2',3'-cyclic phosphoryl and 5'-hydroxyl groups at the termini of the RNA cleavage products (Wreschner DH et al. 1981; Floyd-Smith G et al. 1981; Han Y et al. 2012; Cooper DA et al. 2014). The antiviral function of RNase L extends beyond direct cleavage of viral RNA and includes also cleavage of cellular RNA such as mRNA and rRNA that is required for viral replication (Wreschner DH et al. 1981; Silverman RH et al.1983; Brennan-Laun SE et al. 2014; Cooper DA et al. 2014). RNase L induces apoptosis to eliminate virus-infected cells and autophagy to limit viral infections in some circumstances (Zhou A et al. 1997; Castelli JC et al. 1997; Chakrabarti A et al. 2012). Depending on the cell type and basal levels of RNase L, viral and cellular RNA cleavage products induce signaling to the IFN beta gene through RIG-I and/or MDA5 and MAVS (Malathi K et al. 2007; Banerjee S etl al. 2014).
(summation)	[BlackBoxEvent:9009936] RNASEL cleaves cellular ssRNA [Homo sapiens]
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