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Details on Person The human oligoadenylate synthetase 2 (OAS2) is activated by...

Class:Id	Summation:9012238
_displayName	The human oligoadenylate synthetase 2 (OAS2) is activated by...
_timestamp	2026-03-26 20:59:01
created	[InstanceEdit:9012242] Shamovsky, Veronica, 2017-07-12
literatureReference	[LiteratureReference:8985044] 2'-5' Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of human epithelial cells [LiteratureReference:9009997] Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells [LiteratureReference:8985135] The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities [LiteratureReference:9009992] Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase [LiteratureReference:8985083] Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase
modified	[InstanceEdit:9837745] Orlic-Milacic, Marija, 2023-06-17 [InstanceEdit:9986178] Shamovsky, Veronica, 2026-03-26
text	The human oligoadenylate synthetase 2 (OAS2) is activated by double-stranded RNA (dsRNA) (Hovanessian AG et al. 1988; Sarkar SN et al., 1999, 2002; Behera AK et al. 2002; Kristiansen H et al. 2011).
(summation)	[Reaction:8985138] OAS2 binds viral dsRNA [Homo sapiens]
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