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Details on Person It is believed that Interleukin-1 receptor-associated kinase...

Class:Id	Summation:9012104
_displayName	It is believed that Interleukin-1 receptor-associated kinase...
_timestamp	2017-10-03 10:13:45
created	[InstanceEdit:9012094] Duenas, Corina, 2017-07-11
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:9012409] Interleukin-18 and host defense against infection [LiteratureReference:446699] IRAK: a kinase associated with the interleukin-1 receptor [LiteratureReference:446876] TRAF6 is a signal transducer for interleukin-1
modified	[InstanceEdit:9012434] Duenas, Corina, 2017-07-13 [InstanceEdit:9012493] Duenas, Corina, 2017-07-14 [InstanceEdit:9012494] Duenas, Corina, 2017-07-14 [InstanceEdit:9012997] Duenas, Corina, 2017-07-21 [InstanceEdit:9013296] Duenas, Corina, 2017-07-24 [InstanceEdit:9013348] Duenas, Corina, 2017-07-24 [InstanceEdit:9022964] Duenas, Corina, 2017-09-26 [InstanceEdit:9023024] Duenas, Corina, 2017-09-26 [InstanceEdit:9024301] Duenas, Corina, 2017-10-03
text	It is believed that Interleukin-1 receptor-associated kinase 1 (IRAK1) dissociates from the Interleukin-18 receptor complex (Dinarello & Fantucci 2003, Cao et al. 1996b) paralleling the mechanism of Interleukin-1/IRAK signaling (Cao et al. 1996a). Hyperphosphorylation in the proline-, serine-, and threonine-rich ProST region between the N-terminal death domain and kinase domain of IRAK1 leads to dissociation of IRAK1 from the upstream adapters Myeloid differentiation primary response protein MyD88 (MYD88) and Toll-interacting protein (TOLLIP) but leaves its interaction with the downstream adapter TNF receptor-associated factor 6 (TRAF6) unaffected (Kollewe et al. 2004). This is a black box event because we infer the sites of phosphorylation form Interleukin-1 cascade signaling.
(summation)	[BlackBoxEvent:9012106] p-2S,S376,T,T209,T387-IRAK1 dissociates from IL18:IL18R1:IL18RAP:MYD88 dimer:p-2S,S376,T,T209,T387-IRAK1 [Homo sapiens]
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No pathways have been reviewed or authored by It is believed that Interleukin-1 receptor-associated kinase... (9012104)