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Details on Person FAHD1 dimer hydrolyses OA to PYR

Class:Id	Reaction:9012016
_displayName	FAHD1 dimer hydrolyses OA to PYR
_doRelease	TRUE
_timestamp	2024-04-24 07:25:23
authored	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
catalystActivity	[CatalystActivity:9012042] oxaloacetate decarboxylase activity of FAHD1:Mg2+ dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
crossReference	[DatabaseIdentifier:9861641] RHEA:15642
edited	[InstanceEdit:9012031] Jassal, Bijay, 2017-07-10
input	[SimpleEntity:113587] OA [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:9012047] X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880 [LiteratureReference:9012028] Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase
modified	[InstanceEdit:9012079] Jassal, Bijay, 2017-07-10 [InstanceEdit:9034689] Jassal, Bijay, 2018-01-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861803] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	FAHD1 dimer hydrolyses OA to PYR
output	[SimpleEntity:113557] PYR [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix]
precedingEvent	[Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9861667] DLAT trimer transfers acetyl to CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2018-03-21
reviewed	[InstanceEdit:9034691] Jansen-Duerr, Pidder, Weiss, Alexander, 2018-01-10 [InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9012068] R-HSA-9012016.4
structureModified	[InstanceEdit:9861803] Stephan, Ralf, 2024-02-21
summation	[Summation:9012059] Fumarylacetoacetate hydrolase domain containing protein 1 (F...
(hasEvent)	[Pathway:70268] Pyruvate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:6807826] LDHAL6B reduces PYR to LACT [Homo sapiens] [Reaction:9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Homo sapiens] [Reaction:9861745] Mitochondrial H2O2 decarboxylates PYR to acetate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864198] Update Tracker - [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR - v88:[addInput]
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