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Details on Person PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA

Class:Id	Reaction:901097
_displayName	PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA
_doRelease	TRUE
_timestamp	2025-02-25 22:17:29
authored	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
catalystActivity	[CatalystActivity:901096] L-kynurenine:2-oxoglutarate transaminase activity of CCBL2 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:901099] D'Eustachio, P, 2010-07-02
crossReference	[DatabaseIdentifier:9929637] RHEA:65561
edited	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
inferredFrom	[Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Homo sapiens]
input	[SimpleEntity:29970] L-KYN [cytosol] [SimpleEntity:29406] 2OG [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:901104] Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family
modified	[InstanceEdit:901105] D'Eustachio, P, 2010-07-02 [InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:1004535] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080815] D'Eustachio, P, 2010-11-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA L-kynurenine + 2-oxoglutarate => kynurenate + L-glutamate + H2O
output	[SimpleEntity:893587] KYNA [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:71189] AFMID hydrolyses NFK to L-KYN [Homo sapiens] [Reaction:71188] TDO tetramer dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:198563] IDO1 dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:888614] IDO2 dioxygenates L-Trp to NFK [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105595] R-HSA-901097.3
structureModified	[InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27
summation	[Summation:901098] KYAT3 (CCBL2) catalyzes the reaction of kynurenine and 2-oxo...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:9929658] Deletion of instance: 893609
(updatedInstance)	[_UpdateTracker:9939713] Update Tracker - [Reaction:901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA - v92:[add_removeInput, add_removeOutput, modifyText]
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