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Details on Person MAN1B1 hydrolyses 1,2-linked mannose (c branch)

Class:IdReaction:901039
_displayNameMAN1B1 hydrolyses 1,2-linked mannose (c branch)
_doReleaseTRUE
_timestamp2016-03-03 21:08:54
authored[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity[CatalystActivity:901026] mannosyl-oligosaccharide 1,2-alpha-mannosidase activity of MAN1B1,EDEM2 [endoplasmic reticulum quality control compartment]
compartment[Compartment:927893] endoplasmic reticulum quality control compartment
created[InstanceEdit:901079] Jassal, B, 2010-07-02
edited[InstanceEdit:901079] Jassal, B, 2010-07-02
figure[Figure:1028826] /figures/man8c.png
goBiologicalProcess[GO_BiologicalProcess:6791834] trimming of terminal mannose on C branch
input[Complex:912283] (un)folded protein:(GlcNAc)2 (Man)9 [endoplasmic reticulum quality control compartment] [Homo sapiens]
[SimpleEntity:6781870] H2O [endoplasmic reticulum quality control compartment]
isChimericFALSE
literatureReference[LiteratureReference:1018373] Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis
[LiteratureReference:947811] Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation
[LiteratureReference:6781871] Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control
modified[InstanceEdit:912293] Jassal, B, 2010-07-08
[InstanceEdit:915981] Jassal, B, 2010-07-28
[InstanceEdit:927894] Jassal, B, 2010-08-10
[InstanceEdit:948003] Jassal, B, 2010-09-15
[InstanceEdit:1008193] Jassal, B, 2010-11-10
[InstanceEdit:1018392] Jassal, B, 2010-11-16
[InstanceEdit:1022125] Jassal, B, 2010-11-17
[InstanceEdit:1028800] Jassal, B, 2010-11-18
[InstanceEdit:1028825] Jassal, B, 2010-11-18
[InstanceEdit:6781879] Jassal, Bijay, 2015-06-03
[InstanceEdit:8863064] Weiser, JD, 2016-03-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMAN1B1 hydrolyses 1,2-linked mannose (c branch)
Trimming of the terminal mannose on the C branch
output[Complex:912295] unfolded protein:(GlcNAc)2 (Man)8c [endoplasmic reticulum quality control compartment] [Homo sapiens]
[SimpleEntity:912281] Man [endoplasmic reticulum quality control compartment]
releaseDate2010-12-14
reviewed[InstanceEdit:1028799] Gagneux, P, 2010-11-18
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:6781873] Jassal, Bijay, 2015-06-03
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104854] R-HSA-901039.4
summation[Summation:948025] The enzyme ER Man I can slowly trim up to four of the mannos...
(hasEvent)[Pathway:901032] ER Quality Control Compartment (ERQC) [Homo sapiens]
(normalReaction)[FailedReaction:9036012] Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch) [Homo sapiens]
(precedingEvent)[Reaction:548884] UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b [Homo sapiens]
[Reaction:947991] Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784361] Update Tracker - [Reaction:901039] MAN1B1 hydrolyses 1,2-linked mannose (c branch) - v54:[addInput, add_removeLiteratureReference, modifyText]
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