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Query author contributions in Reactome
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Details on Person MAN1B1 hydrolyses 1,2-linked mannose (a branch)
MAN1B1 hydrolyses (un)folded protein:(GlcNAc)2 (Man)9 to unfolded protein:(GlcNAc)2 (Man)8a, cleaving a mannose moiety from the a branch of the N-glycan precursor (Gonzalez et al. 1999, Karaveg et al. 2005, Avezov et al. 2008). This is a critical mannose residue, the glucose acceptor, so when removed, it precludes the glycoprotein from association with CNX and targeting it to ER–associated degradation (ERAD).
