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Details on Person RNASEL cleaves cellular ssRNA

Class:IdBlackBoxEvent:9009936
_displayNameRNASEL cleaves cellular ssRNA
_doReleaseTRUE
_timestamp2026-04-27 15:38:54
authored[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity[CatalystActivity:9009939] RNA endonuclease activity of RNASEL:2'-5' oligoadenylate [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9009930] Shamovsky, Veronica, 2017-06-23
edited[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
input[OtherEntity:170292] ssRNA [cytosol]
internalReviewed[InstanceEdit:9987721] Stephan, Ralf, 2026-04-27
isChimericFALSE
literatureReference[LiteratureReference:9009969] Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs
[LiteratureReference:9614477] rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells
modified[InstanceEdit:9012242] Shamovsky, Veronica, 2017-07-12
[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9037722] Shamovsky, Veronica, 2018-02-20
[InstanceEdit:9038307] Shamovsky, Veronica, 2018-02-24
[InstanceEdit:9038502] Shamovsky, Veronica, 2018-02-28
[InstanceEdit:9615060] Shamovsky, Veronica, 2018-07-31
[InstanceEdit:9615278] Shamovsky, Veronica, 2018-07-31
[InstanceEdit:9616210] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9987722] Shamovsky, Veronica, 2026-04-27
nameRNASEL cleaves cellular ssRNA
RNASEL cleaves cellular ssRNA to generate 5'-OH, 2'-3' cyclic phosphate RNA fragments
output[OtherEntity:9009945] RNA fragment with 2'-3' cyclic phosphate [cytosol]
precedingEvent
releaseDate2018-09-12
reviewed[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9009986] R-HSA-9009936.2
summation[Summation:9012239] Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain c...
(hasEvent)[Pathway:8983711] OAS antiviral response [Homo sapiens]
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