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Details on Person Interleukin-34 (IL34) is involved in the survival, prolifera...
| Class:Id | Summation:9009552 |
|---|---|
| _displayName | Interleukin-34 (IL34) is involved in the survival, prolifera... |
| _timestamp | 2017-11-03 14:59:19 |
| created | [InstanceEdit:9009555] Varusai, Thawfeek, 2017-06-20 |
| literatureReference | [LiteratureReference:9009556] Syndecan-1 regulates the biological activities of interleukin-34 |
| modified | [InstanceEdit:9011377] Jupe, Steve, 2017-06-30 [InstanceEdit:9027647] Jupe, Steve, 2017-11-03 |
| text | Interleukin-34 (IL34) is involved in the survival, proliferation and differentiation of monocytes and macrophages. Syndecan-1 (SDC1) is a cell surface proteoglycan that contains the chondroitin sulphate and primarily functions to link the cytoskeleton to the interstitial matrix. IL34 dimers can bind to the chondroitin sulphate of SDC1. Subsequently, SDC1 modulates IL34-induced CSF1R signaling pathways (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. |
| (summation) | [Reaction:9009558] IL34 dimer binds SDC1 [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-34 (IL34) is involved in the survival, prolifera... (9009552)
