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Details on Person Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell sur...
| Class:Id | Summation:9009551 |
|---|---|
| _displayName | Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell sur... |
| _timestamp | 2017-11-03 14:59:17 |
| created | [InstanceEdit:9009555] Varusai, Thawfeek, 2017-06-20 |
| literatureReference | [LiteratureReference:9009556] Syndecan-1 regulates the biological activities of interleukin-34 |
| modified | [InstanceEdit:9011377] Jupe, Steve, 2017-06-30 [InstanceEdit:9027647] Jupe, Steve, 2017-11-03 |
| text | Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell surface proteoglycan. Low levels of SDC1 may sequester IL34 at the cell surface and prevent it from binding Macrophage colony-stimulating factor 1 receptor (CSF1R), while high SDC1 levels may facilitate IL34-CSF1R signaling (Segaliny et al. 2015). Ultimately, these events lead to the release of pro-inflammatory chemokines regulating the innate immunity and inflammation. The precise interaction between IL34:SDC1 and CSF1R is unknown. Hence, this interaction is represented as an uncertain black box event. |
| (summation) | [BlackBoxEvent:9009554] IL34 dimer:SDC1 binds CSF1R [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukin-34 (IL34) can bind Syndecan-1 (SDC1), a cell sur... (9009551)
