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Details on Person RUNX2 binds BAX gene promoter

Class:IdReaction:9008832
_displayNameRUNX2 binds BAX gene promoter
_doReleaseTRUE
_timestamp2017-08-14 17:55:04
authored[InstanceEdit:9008829] Orlic-Milacic, Marija, 2017-06-13
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9008829] Orlic-Milacic, Marija, 2017-06-13
edited[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
input[Complex:8865420] RUNX2:CBFB [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:3700977] BAX gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9008841] Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio
[LiteratureReference:9008840] Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents
[LiteratureReference:9008835] Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
modified[InstanceEdit:9008860] Orlic-Milacic, Marija, 2017-06-13
[InstanceEdit:9014260] Orlic-Milacic, Marija, 2017-07-27
[InstanceEdit:9015326] Orlic-Milacic, Marija, 2017-08-09
[InstanceEdit:9015396] Orlic-Milacic, Marija, 2017-08-10
[InstanceEdit:9015625] Orlic-Milacic, Marija, 2017-08-10
[InstanceEdit:9016598] Orlic-Milacic, Marija, 2017-08-14
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRUNX2 binds BAX gene promoter
output[Complex:9008858] RUNX2:CBFB:BAX gene [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9008865] Positive regulation by 'BMP2 dimer [extracellular region]'
regulationReference[RegulationReference:9642221] Positive regulation by 'BMP2 dimer [extracellular region]' Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
releaseDate2017-09-12
reviewed[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9008845] R-HSA-9008832.4
summation[Summation:9008856] RUNX2, presumably in complex with CBFB, binds the promoter o...
(hasEvent)[Pathway:8878166] Transcriptional regulation by RUNX2 [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9008839] BAX gene expression is stimulated by RUNX2 [Homo sapiens]
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