Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Based on studies in mice, RUNX2 forms a complex with HEY2 (H...
| Class:Id | Summation:9008187 |
|---|---|
| _displayName | Based on studies in mice, RUNX2 forms a complex with HEY2 (H... |
| _timestamp | 2017-06-16 18:42:10 |
| created | [InstanceEdit:9008186] Orlic-Milacic, Marija, 2017-06-07 |
| modified | [InstanceEdit:9008195] Orlic-Milacic, Marija, 2017-06-07 [InstanceEdit:9008210] Orlic-Milacic, Marija, 2017-06-07 [InstanceEdit:9009285] Orlic-Milacic, Marija, 2017-06-16 |
| text | Based on studies in mice, RUNX2 forms a complex with HEY2 (HRT2), a product of the NOTCH1 target gene. Binding to HEY2 inhibits RUNX2-mediated transcriptional activation of the BGLAP (Osteocalcin) gene (Garg et al. 2005). Other NOTCH1 targets, HEY1 and HES1, can also bind to RUNX2 and inhibit RUNX2 transcriptional activity (Hilton et al. 2008). NOTCH1 mutations cause severe aortic valve calcification in humans, which may be due to impaired repression of RUNX2-mediated transcription (Garg et al. 2005). NOTCH-mediated inhibition of RUNX2 transcriptional activity is also implicated in the maintenance of mesenchymal progenitors in the bone marrow by suppression of osteoblast differentiation (Hilton et al. 2008). NOTCH1 may also inhibit RUNX2-mediated activation of target promoters by formation of a complex between RUNX2 and NOTCH1 intracellular domain (NICD1) (Engin et al. 2008). |
| (summation) | [Reaction:9008177] RUNX2 binds HEY1,HEY2,HES1 [Homo sapiens] |
| [Change default viewing format] | |
