Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)

Class:Id	BlackBoxEvent:9007686
_displayName	RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)
_doRelease	TRUE
_timestamp	2017-12-05 04:40:37
authored	[InstanceEdit:9007688] Orlic-Milacic, Marija, 2017-06-01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9007688] Orlic-Milacic, Marija, 2017-06-01
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
inferredFrom	[BlackBoxEvent:8985328] Runx2 gene transcription is repressed by Nkx3-2 and Msx2, and activated by Dlx5,(Dlx6) [Mus musculus]
input	[EntityWithAccessionedSequence:8939903] RUNX2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8985294] Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation [LiteratureReference:8985304] Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation [LiteratureReference:9007714] Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter [LiteratureReference:9007782] The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development [LiteratureReference:9008350] Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene
modified	[InstanceEdit:9007720] Orlic-Milacic, Marija, 2017-06-02 [InstanceEdit:9007775] Orlic-Milacic, Marija, 2017-06-02 [InstanceEdit:9007784] Orlic-Milacic, Marija, 2017-06-05 [InstanceEdit:9007810] Orlic-Milacic, Marija, 2017-06-05 [InstanceEdit:9007997] Orlic-Milacic, Marija, 2017-06-06 [InstanceEdit:9008377] Orlic-Milacic, Marija, 2017-06-08 [InstanceEdit:9008378] Orlic-Milacic, Marija, 2017-06-08 [InstanceEdit:9014260] Orlic-Milacic, Marija, 2017-07-27 [InstanceEdit:9015326] Orlic-Milacic, Marija, 2017-08-09 [InstanceEdit:9015396] Orlic-Milacic, Marija, 2017-08-10 [InstanceEdit:9016544] Orlic-Milacic, Marija, 2017-08-14 [InstanceEdit:9016598] Orlic-Milacic, Marija, 2017-08-14 [InstanceEdit:9032008] Orlic-Milacic, Marija, 2017-12-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)
output	[EntityWithAccessionedSequence:9007983] RUNX2-P1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8985293] NKX3-2 binds RUNX2 gene promoter [Homo sapiens] [BlackBoxEvent:8985354] NKX3-2 gene expression is stimulated by SOX9 [Homo sapiens] [Reaction:9008345] RUNX2-P1 binds RUNX2 gene promoter [Homo sapiens] [BlackBoxEvent:9007999] RUNX2 translocates to the nucleus [Homo sapiens] [Reaction:9007707] DLX5,(DLX6) binds RUNX2 gene promoter [Homo sapiens] [Reaction:9007759] MSX2 binds RUNX2 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:8985309] Negative gene expression regulation by 'NKX3-2:RUNX2 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9007725] Positive gene expression regulation by 'DLX5,(DLX6):RUNX2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9007772] Negative gene expression regulation by 'MSX2:RUNX2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9008381] Negative gene expression regulation by 'RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642540] Negative gene expression regulation by 'RUNX2-P1:CBFB:RUNX2 gene [nucleoplasm]' Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene [RegulationReference:9642654] Negative gene expression regulation by 'MSX2:RUNX2 gene [nucleoplasm]' Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter [RegulationReference:9642759] Negative gene expression regulation by 'NKX3-2:RUNX2 gene [nucleoplasm]' Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation [RegulationReference:9642898] Positive gene expression regulation by 'DLX5,(DLX6):RUNX2 gene [nucleoplasm]' Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
releaseDate	2017-09-12
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9007693] R-HSA-9007686.5
summation	[Summation:9007692] Based on studies in mice, RUNX2 transcription is repressed b...
(hasEvent)	[Pathway:8939902] Regulation of RUNX2 expression and activity [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9007999] RUNX2 translocates to the nucleus [Homo sapiens] [Reaction:9008015] RUNX2 binds STAT1 [Homo sapiens] [Reaction:9008036] RUNX2 binds to HIVEP3 and WWP1 [Homo sapiens] [Reaction:9009309] RUNX2 binds STUB1 [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (9007686)