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Details on Person Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2

Class:Id	BlackBoxEvent:9007126
_displayName	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2
_doRelease	TRUE
_timestamp	2017-08-22 21:34:28
authored	[InstanceEdit:9014998] Duenas, Corina, 2017-08-07
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9007160] Duenas, Corina, 2017-05-26
edited	[InstanceEdit:9015191] Duenas, Corina, 2017-08-09
input	[Complex:8983178] Il15:Il15ra:p-Y-Il2rb:p-Y-Il2rg:p-Y-Jak1:p-Y-Jak3:p-Y-Shc:Grb2 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:2685613] Gab2 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:8983426] A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes [LiteratureReference:8983353] How to Grb2 a Gab [LiteratureReference:8983265] The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
modified	[InstanceEdit:9007328] Duenas, Corina, 2017-05-30 [InstanceEdit:9009893] Duenas, Corina, 2017-06-23 [InstanceEdit:9011616] Duenas, Corina, 2017-07-03 [InstanceEdit:9011624] Duenas, Corina, 2017-07-03 [InstanceEdit:9015193] Duenas, Corina, 2017-08-09 [InstanceEdit:9017583] Duenas, Corina, 2017-08-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2 Gab2 binds to the Il15ra:Il15:Il2rb:JAK1:Il2rg:p-Jak3:p-Y-Shc1:Grb2 complex
output	[Complex:9007143] Il15:Il15ra:p-Y-Il2rb:p-Y-Il2rg:p-Y-Jak1:p-Y-Jak3:p-Y-Shc:Grb2:Gab2 [plasma membrane] [Mus musculus]
precedingEvent	[BlackBoxEvent:8983356] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2 [Mus musculus] [BlackBoxEvent:8983294] Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1 [Mus musculus]
releaseDate	2017-09-12
reviewed	[InstanceEdit:9014997] Patidar, Manoj, 2017-08-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9007179] R-MMU-9007126.2
summation	[Summation:9007125] Grb2 associated binding protein 2 (Gab2) is believed to bind...
(inferredFrom)	[BlackBoxEvent:8983425] IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9007137] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2 [Mus musculus]
(updatedInstance)	[_UpdateTracker:9780441] Update Tracker - [BlackBoxEvent:9007126] Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2 - v63:[modifyText]
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No pathways have been reviewed or authored by Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2 (9007126)