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Details on Person Epo binds Epor:Jak2:Lyn:Irs2

Class:IdReaction:9006326
_displayNameEpo binds Epor:Jak2:Lyn:Irs2
_doReleaseTRUE
_timestamp2018-08-14 15:49:21
authored[InstanceEdit:9006330] May, Bruce, 2017-04-22
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9006333] May, Bruce, 2017-05-13
edited[InstanceEdit:9006330] May, Bruce, 2017-04-22
input[EntityWithAccessionedSequence:9006278] Epo [extracellular region] [Mus musculus]
[Complex:9006302] Epor:Jak2:Lyn:Irs2 [plasma membrane] [Mus musculus]
isChimericFALSE
literatureReference[LiteratureReference:1364060] Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
[LiteratureReference:9006198] Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
[LiteratureReference:9006228] Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function
[LiteratureReference:9006193] Expression cloning of the murine erythropoietin receptor
[LiteratureReference:9006152] Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
[LiteratureReference:9006199] Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function
[LiteratureReference:9027182] Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway
[LiteratureReference:9027418] Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells
[LiteratureReference:9027143] Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation
[LiteratureReference:9029059] Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn
[LiteratureReference:9030310] Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains
[LiteratureReference:208315] JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
[LiteratureReference:9006226] Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction
modified[InstanceEdit:9009420] May, Bruce, 2017-06-17
[InstanceEdit:9012667] May, Bruce, 2017-07-17
[InstanceEdit:9027297] May, Bruce, 2017-10-29
[InstanceEdit:9027444] May, Bruce, 2017-11-01
[InstanceEdit:9029175] May, Bruce, 2017-11-14
[InstanceEdit:9030341] May, Bruce, 2017-11-27
[InstanceEdit:9616794] Matthews, Lisa, 2018-08-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameEpo binds Epor:Jak2:Lyn:Irs2
output[Complex:9006304] Epo:Epor:Jak2:Lyn:Irs2 [plasma membrane] [Mus musculus]
releaseDate2018-09-12
reviewed[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9006340] R-MMU-9006326.2
summation[Summation:9030333] Extracellular Erythropoietin (Epo) binds the Epo receptor (E...
(inferredFrom)[Reaction:9006325] EPO binds EPOR:JAK2:LYN:IRS2 [Homo sapiens]
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