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Details on Person MECP2:SIN3A complex binds the promoter of the BDNF gene

Class:IdReaction:9006050
_displayNameMECP2:SIN3A complex binds the promoter of the BDNF gene
_doReleaseTRUE
_timestamp2018-08-08 18:51:02
authored[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9006053] Orlic-Milacic, Marija, 2017-05-11
edited[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
inferredFrom
input[EntityWithAccessionedSequence:9006123] BDNF gene [nucleoplasm] [Homo sapiens]
[Complex:9022425] MECP2:SIN3A:HDAC1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9006059] DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
[LiteratureReference:9006052] Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
modified[InstanceEdit:9006128] Orlic-Milacic, Marija, 2017-05-12
[InstanceEdit:9006143] Orlic-Milacic, Marija, 2017-05-12
[InstanceEdit:9006359] Orlic-Milacic, Marija, 2017-05-15
[InstanceEdit:9022443] Orlic-Milacic, Marija, 2017-09-22
[InstanceEdit:9605001] Orlic-Milacic, Marija, 2018-04-06
[InstanceEdit:9608108] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608115] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608122] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608281] Orlic-Milacic, Marija, 2018-05-11
[InstanceEdit:9615853] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615854] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615857] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9615861] Orlic-Milacic, Marija, 2018-08-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMECP2:SIN3A complex binds the promoter of the BDNF gene
output[Complex:9006120] MECP2:SIN3A:HDAC1:BDNF gene [nucleoplasm] [Homo sapiens]
releaseDate2018-09-12
reviewed[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07
[InstanceEdit:9608114] Christodoulou, John, 2018-08-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9006060] R-HSA-9006050.2
summation[Summation:9006357] Based on studies in mice, the complex of MECP2, SIN3A and HD...
(hasEvent)[Pathway:9022702] MECP2 regulates transcription of neuronal ligands [Homo sapiens]
(normalReaction)[FailedReaction:9023461] MECP2 T158A:SIN3A complex does not bind BDNF gene promoter [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9006122] BDNF gene transcription [Homo sapiens]
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No pathways have been reviewed or authored by MECP2:SIN3A complex binds the promoter of the BDNF gene (9006050)