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Details on Person Active Prkaca and CaMK IV phosphorylate Mecp2 at T308

Class:Id	Reaction:9005848
_displayName	Active Prkaca and CaMK IV phosphorylate Mecp2 at T308
_doRelease	TRUE
_timestamp	2018-08-08 18:45:43
authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
catalystActivity	[CatalystActivity:9005851] calcium,diacylglycerol-dependent serine/threonine kinase activity of Active Prkaca,CaMKIV [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9005847] Orlic-Milacic, Marija, 2017-05-10
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
input	[EntityWithAccessionedSequence:9005845] Mecp2_e2 [nucleoplasm] [Mus musculus] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
modified	[InstanceEdit:9608108] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608112] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608115] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608122] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608281] Orlic-Milacic, Marija, 2018-05-11 [InstanceEdit:9615854] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615857] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615859] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active Prkaca and CaMK IV phosphorylate Mecp2 at T308
output	[EntityWithAccessionedSequence:9005849] p-T308-Mecp2_e2 [nucleoplasm] [Mus musculus] [SimpleEntity:113582] ADP [nucleoplasm]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9608114] Christodoulou, John, 2018-08-07 [InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9005853] R-MMU-9005848.2
summation	[Summation:9005844] Recombinant mouse Prkaca (PKA C-alpha), as well as the activ...
(inferredFrom)	[Reaction:8986937] MECP2 is phosphorylated at T308 [Homo sapiens]
(normalReaction)	[FailedReaction:9005872] Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308 [Mus musculus]
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No pathways have been reviewed or authored by Active Prkaca and CaMK IV phosphorylate Mecp2 at T308 (9005848)