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Details on Person Diagram of Transcriptional Regulation by MECP2, Loss of MECP2 binding ability to 5mC-DNA, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of MECP2 binding ability to 5hmC-DNA, and Loss of phosphorylation of MECP2 at T308
| Class:Id | PathwayDiagram:9005582 |
|---|---|
| _displayName | Diagram of Transcriptional Regulation by MECP2, Loss of MECP2 binding ability to 5mC-DNA, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of MECP2 binding ability to 5hmC-DNA, and Loss of phosphorylation of MECP2 at T308 |
| _timestamp | 2024-01-04 16:41:48 |
| created | [InstanceEdit:9005571] Orlic-Milacic, Marija, 2017-05-09 |
| height | 1641 |
| modified | [InstanceEdit:9005711] Orlic-Milacic, Marija, 2017-05-09 [InstanceEdit:9005859] Orlic-Milacic, Marija, 2017-05-10 [InstanceEdit:9006001] Orlic-Milacic, Marija, 2017-05-11 [InstanceEdit:9006013] Orlic-Milacic, Marija, 2017-05-11 [InstanceEdit:9006029] Orlic-Milacic, Marija, 2017-05-11 [InstanceEdit:9006128] Orlic-Milacic, Marija, 2017-05-12 [InstanceEdit:9006486] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9006524] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9006539] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9006551] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9006566] Orlic-Milacic, Marija, 2017-05-16 [InstanceEdit:9006839] Orlic-Milacic, Marija, 2017-05-22 [InstanceEdit:9006843] Orlic-Milacic, Marija, 2017-05-22 [InstanceEdit:9007012] Orlic-Milacic, Marija, 2017-05-25 [InstanceEdit:9007041] Orlic-Milacic, Marija, 2017-05-26 [InstanceEdit:9012758] Orlic-Milacic, Marija, 2017-07-18 [InstanceEdit:9017362] Orlic-Milacic, Marija, 2017-08-18 [InstanceEdit:9017465] Orlic-Milacic, Marija, 2017-08-21 [InstanceEdit:9017474] Orlic-Milacic, Marija, 2017-08-21 [InstanceEdit:9017917] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9017935] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9017965] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9017966] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9017968] Orlic-Milacic, Marija, 2017-08-28 [InstanceEdit:9018000] Orlic-Milacic, Marija, 2017-08-29 [InstanceEdit:9018006] Orlic-Milacic, Marija, 2017-08-29 [InstanceEdit:9018007] Orlic-Milacic, Marija, 2017-08-29 [InstanceEdit:9018011] Orlic-Milacic, Marija, 2017-08-29 [InstanceEdit:9018015] Orlic-Milacic, Marija, 2017-08-29 [InstanceEdit:9020510] Orlic-Milacic, Marija, 2017-09-06 [InstanceEdit:9020511] Orlic-Milacic, Marija, 2017-09-06 [InstanceEdit:9020532] Orlic-Milacic, Marija, 2017-09-06 [InstanceEdit:9020549] Orlic-Milacic, Marija, 2017-09-06 [InstanceEdit:9020963] Orlic-Milacic, Marija, 2017-09-12 [InstanceEdit:9021019] Orlic-Milacic, Marija, 2017-09-13 [InstanceEdit:9021095] Orlic-Milacic, Marija, 2017-09-13 [InstanceEdit:9021191] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9021204] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9021211] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9021220] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9021239] Orlic-Milacic, Marija, 2017-09-15 [InstanceEdit:9021871] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9021902] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9021930] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9021943] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022075] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022101] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022102] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022137] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022204] Orlic-Milacic, Marija, 2017-09-21 [InstanceEdit:9022343] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022371] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022391] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022397] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022398] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022443] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022472] Orlic-Milacic, Marija, 2017-09-22 [InstanceEdit:9022547] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9022641] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9022763] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9022777] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9022796] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9022799] Orlic-Milacic, Marija, 2017-09-25 [InstanceEdit:9023005] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023025] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023026] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023027] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023037] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023038] Orlic-Milacic, Marija, 2017-09-26 [InstanceEdit:9023386] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023403] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023404] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023405] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023406] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023556] Orlic-Milacic, Marija, 2017-09-27 [InstanceEdit:9023614] Orlic-Milacic, Marija, 2017-09-28 [InstanceEdit:9023721] Orlic-Milacic, Marija, 2017-09-28 [InstanceEdit:9023723] Orlic-Milacic, Marija, 2017-09-28 [InstanceEdit:9023902] Orlic-Milacic, Marija, 2017-09-28 [InstanceEdit:9604964] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9604967] Orlic-Milacic, Marija, 2018-04-06 [InstanceEdit:9604993] Orlic-Milacic, Marija, 2018-04-06 [InstanceEdit:9604996] Orlic-Milacic, Marija, 2018-04-06 [InstanceEdit:9615497] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9615498] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9615502] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9615545] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9615677] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9615777] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615783] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615787] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615788] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615790] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615800] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615824] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615834] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9615835] Orlic-Milacic, Marija, 2018-08-08 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9857429] Orlic-Milacic, Marija, 2024-01-04 |
| representedPathway | [Pathway:8986944] Transcriptional Regulation by MECP2 [Homo sapiens] [Pathway:9022538] Loss of MECP2 binding ability to 5mC-DNA [Homo sapiens] [Pathway:9022537] Loss of MECP2 binding ability to the NCoR/SMRT complex [Homo sapiens] [Pathway:9022534] Loss of MECP2 binding ability to 5hmC-DNA [Homo sapiens] [Pathway:9022535] Loss of phosphorylation of MECP2 at T308 [Homo sapiens] |
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</org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="923" reactomeId="9017956" position="1982 1257" bounds="1929 1233 106 48" textPosition="1931 1231" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:SIN3A:HDAC1:HDAC1:OPRM1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="965" reactomeId="9017971" position="740 354" bounds="715 329 50 51" textPosition="721 356"> <Properties> <displayName>CRH gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="966" reactomeId="9017996" position="831 297" bounds="796 281 71 33" textPosition="798 278" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:CRH gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="998" reactomeId="420146" position="764 59" bounds="748 48 33 23" textPosition="748 48"> <Properties> <displayName>CRH</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1000" reactomeId="194637" position="1283 227" bounds="1268 216 30 22" textPosition="1268 216"> <Properties> <displayName>LBR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1001" reactomeId="9018599" position="1365 231" bounds="1327 220 76 22" textPosition="1329 220" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:LBR</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1017" reactomeId="9020501" position="1691 792" bounds="1664 767 54 51" textPosition="1663 794"> <Properties> <displayName>GRIN2B gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1018" reactomeId="9020506" position="1959 725" bounds="1893 713 133 24" textPosition="1895 715" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:GRIN2B gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1070" reactomeId="419558" position="2367 775" bounds="2341 764 53 22" textPosition="2341 764"> <Properties> <displayName>GRIN2B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1096" reactomeId="9021177" position="1183 134" bounds="1134 123 99 23" textPosition="1139 123" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>miR-132 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1098" reactomeId="9021180" position="1060 188" bounds="968 176 184 24" textPosition="974 178" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2 mRNA:miR-132 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1204" reactomeId="9021217" position="941 132" bounds="897 121 89 22" textPosition="897 121"> <Properties> <displayName>MECP2 mRNA</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1267" reactomeId="8962680" position="323 622" bounds="297 597 53 51" textPosition="299 624"> <Properties> <displayName>CREB1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1268" reactomeId="9021865" position="438 732" bounds="395 713 86 39" textPosition="399 716" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:CREB1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1282" reactomeId="52777" position="305 743" bounds="278 732 54 23" textPosition="282 732"> <Properties> <displayName>CREB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1338" reactomeId="9021896" position="241 691" bounds="211 667 60 48" textPosition="213 665" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:p-S133-CREB1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1399" reactomeId="9021905" position="233 467" bounds="211 442 45 51" textPosition="215 469"> <Properties> <displayName>SST gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1400" reactomeId="9021924" position="400 337" bounds="367 307 66 60" textPosition="368 303" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:p-S133-CREB1:SST gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1424" reactomeId="374714" position="299 56" bounds="256 45 87 22" textPosition="256 45"> <Properties> <displayName>Somatostatin</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1660" reactomeId="9021994" position="1739 961" bounds="1713 936 52 51" textPosition="1713 963"> <Properties> <displayName>OPRK1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1661" reactomeId="9021993" position="2005 939" bounds="1963 923 85 32" textPosition="1965 919" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:OPRK1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1667" reactomeId="374286" position="2362 974" bounds="2338 963 49 22" textPosition="2339 963"> <Properties> <displayName>OPRK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1669" reactomeId="8962696" position="933 1280" bounds="903 1255 61 51" textPosition="909 1282"> <Properties> <displayName>GAMT gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1670" reactomeId="9022024" position="1059 1263" bounds="1020 1245 79 36" textPosition="1021 1245" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:GAMT gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1672" reactomeId="71276" position="994 1504" bounds="972 1493 45 22" textPosition="972 1493"> <Properties> <displayName>GAMT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1674" reactomeId="8961331" position="1671 1056" bounds="1640 1031 62 51" textPosition="1643 1058"> <Properties> <displayName>GPRIN1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1675" reactomeId="9022056" position="1920 1027" bounds="1875 1010 91 34" textPosition="1878 1008" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:GPRIN1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1677" reactomeId="9022059" position="2360 1060" bounds="2334 1049 53 22" textPosition="2335 1049"> <Properties> <displayName>GPRIN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1735" reactomeId="9022086" position="208 956" bounds="182 931 53 51" textPosition="182 958"> <Properties> <displayName>MEF2C gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1736" reactomeId="9022092" position="337 1009" bounds="296 993 83 33" textPosition="297 990" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:MEF2C gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1738" reactomeId="199938" position="232 1087" bounds="208 1076 48 22" textPosition="208 1076"> <Properties> <displayName>MEF2C</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1824" reactomeId="9022117" position="354 1178" bounds="327 1153 54 51" textPosition="329 1180"> <Properties> <displayName>RBFOX1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1825" reactomeId="9022121" position="318 1100" bounds="272 1084 92 32" textPosition="274 1080" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:RBFOX1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1827" reactomeId="400307" position="254 1166" bounds="227 1155 55 22" textPosition="227 1155"> <Properties> <displayName>RBFOX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1940" reactomeId="9022188" position="1866 357" bounds="1840 332 52 51" textPosition="1841 359"> <Properties> <displayName>SLC2A3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1941" reactomeId="9022198" position="1976 269" bounds="1902 252 148 34" textPosition="1906 250" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:p-S133-CREB1:SLC2A3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1947" reactomeId="70407" position="2362 351" bounds="2336 340 53 22" textPosition="2339 333"> <Properties> <displayName>SLC2A3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2038" reactomeId="9022332" position="917 907" bounds="867 896 101 22" textPosition="874 896"> <Properties> <displayName>p-S80-MECP2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="2040" reactomeId="3215222" position="846 859" bounds="824 848 45 22" textPosition="825 848"> <Properties> <displayName>HIPK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2042" reactomeId="1482509" position="812 816" bounds="783 806 58 21" textPosition="787 806"> <Properties> <displayName>DGCR8</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2043" reactomeId="9022340" position="864 719" bounds="817 708 95 22" textPosition="818 708" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:DGCR8</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2179" reactomeId="9022386" position="1761 513" bounds="1735 488 53 51" textPosition="1737 515"> <Properties> <displayName>GRIA2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2180" reactomeId="9022393" position="1947 421" bounds="1897 396 101 51" textPosition="1899 383" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:SIN3A:HDAC1:HDAC2:GRIA2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2182" reactomeId="3004502" position="2355 483" bounds="2331 472 49 23" textPosition="2333 472"> <Properties> <displayName>GRIA2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2203" reactomeId="9022431" position="627 544" bounds="580 526 95 36" textPosition="580 526" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>SIN3A:HDAC1,HDAC2 dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="2205" reactomeId="9022422" position="691 469" bounds="640 447 103 45" textPosition="643 451"> <Properties> <displayName>MECP2:SIN3A:HDAC1,HDAC2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2207" reactomeId="9022425" position="563 469" bounds="518 451 91 36" textPosition="518 451" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:SIN3A:HDAC1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="2273" reactomeId="9022447" position="1285 349" bounds="1251 338 69 22" textPosition="1252 338"> <Properties> <displayName>5mC-DNA</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="2274" reactomeId="9022463" position="1330 300" bounds="1272 289 117 23" textPosition="1276 290" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:5mC-DNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="2276" reactomeId="9022446" position="1433 435" bounds="1395 424 76 22" textPosition="1396 424"> <Properties> <displayName>5hmC-DNA</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="2277" reactomeId="9022466" position="1422 383" bounds="1362 372 120 22" textPosition="1364 372" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:5hmC-DNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2370" reactomeId="9022629" position="1190 358" bounds="1164 346 52 24" textPosition="1165 347"> <Properties> <displayName>FOXG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2371" reactomeId="9022636" position="1257 407" bounds="1226 391 62 33" textPosition="1231 388" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:FOXG1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="2472" reactomeId="9022741" position="1666 1296" bounds="1641 1271 50 51" textPosition="1642 1298"> <Properties> <displayName>FKBP5 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2473" reactomeId="9022756" position="1623 1397" bounds="1585 1379 76 37" textPosition="1597 1366" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:FKBP5 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2475" reactomeId="5618096" position="1702 1516" bounds="1680 1505 45 22" textPosition="1680 1505"> <Properties> <displayName>FKBP5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2576" reactomeId="9022779" position="863 1190" bounds="840 1165 47 51" textPosition="841 1192"> <Properties> <displayName>SGK1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2577" reactomeId="9022789" position="956 1184" bounds="919 1167 74 35" textPosition="919 1166" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:SGK1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2579" reactomeId="2682356" position="864 1508" bounds="839 1496 51 25" textPosition="844 1497"> <Properties> <displayName>SGK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2649" reactomeId="5640205" position="309 1287" bounds="278 1262 62 51" textPosition="284 1289"> <Properties> <displayName>PPARG gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableGene id="2678" reactomeId="9022972" position="1520 413" bounds="1496 388 48 51" textPosition="1496 415"> <Properties> <displayName>GAD1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2679" reactomeId="9022984" position="1609 324" bounds="1571 306 77 37" textPosition="1571 307" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:GAD1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2686" reactomeId="888580" position="1479 203" bounds="1421 192 117 22" textPosition="1425 192"> <Properties> <displayName>PXLP-K405-GAD1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1452991452991453" relativeY="0.0" label="PP" trackId="0" reactomeId="9644713" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="2687" reactomeId="917757" position="1567 172" bounds="1474 135 187 74" textPosition="1476 141" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane</displayName> </Properties> <Components> <Component id="2686" /> <Component id="2692" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="2689" reactomeId="9022970" position="1650 405" bounds="1624 380 53 51" textPosition="1627 407"> <Properties> <displayName>GAD2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2690" reactomeId="9022982" position="1727 299" bounds="1687 282 80 34" textPosition="1689 280" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:GAD2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2692" reactomeId="888582" position="1633 206" bounds="1575 195 117 22" textPosition="1579 195"> <Properties> <displayName>PXLP-K396-GAD2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1452991452991453" relativeY="0.0" label="PP" trackId="0" reactomeId="9644715" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2741" reactomeId="9022903" position="1051 1327" bounds="1027 1302 49 51" textPosition="1029 1329"> <Properties> <displayName>MOBP gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2742" reactomeId="9022904" position="1167 1380" bounds="1130 1362 75 37" textPosition="1130 1363" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:MOBP gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2744" reactomeId="9022884" position="1104 1509" bounds="1083 1498 42 22" textPosition="1083 1498"> <Properties> <displayName>MOBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2816" reactomeId="1911481" position="1656 1145" bounds="1626 1120 61 51" textPosition="1626 1147"> <Properties> <displayName>NOTCH1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2817" reactomeId="9023372" position="1923 1120" bounds="1874 1103 98 35" textPosition="1877 1102" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:NOTCH1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="2819" reactomeId="1606559" position="2159 1129" bounds="2106 1109 107 40" textPosition="2110 1118"> <Properties> <displayName>NOTCH1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableGene id="2874" reactomeId="9023392" position="594 296" bounds="570 271 49 51" textPosition="574 298"> <Properties> <displayName>DLL1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2875" reactomeId="9023387" position="686 274" bounds="645 256 83 36" textPosition="645 256" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:DLL1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2882" reactomeId="157089" position="571 99" bounds="552 88 38 22" textPosition="552 88"> <Properties> <displayName>DLL1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="2905" reactomeId="157118" position="670 105" bounds="617 80 106 50" textPosition="624 83"> <Properties> <displayName>Signaling by NOTCH</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="2907" reactomeId="1912422" position="2313 1128" bounds="2252 1094 122 68" textPosition="2259 1099"> <Properties> <displayName>Pre-NOTCH Expression and Processing</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="2924" reactomeId="4655360" position="780 874" bounds="756 863 48 22" textPosition="756 863"> <Properties> <displayName>AURKB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="2966" reactomeId="9023541" position="1346 1075" bounds="1316 1050 60 51" textPosition="1322 1077"> <Properties> <displayName>PTPN1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2967" reactomeId="9023531" position="1433 1392" bounds="1389 1374 88 36" textPosition="1388 1374" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:PTPN1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2979" reactomeId="210625" position="1374 1534" bounds="1344 1523 61 22" textPosition="1352 1523"> <Properties> <displayName>PTPN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2981" reactomeId="9023590" position="579 590" bounds="562 579 34 22" textPosition="563 579"> <Properties> <displayName>HTT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2982" reactomeId="9023598" position="481 612" bounds="454 595 54 35" textPosition="455 594" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:HTT</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2996" reactomeId="111911" position="949 395" bounds="898 377 103 36" textPosition="901 377" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableGene id="2997" reactomeId="9615492" position="1062 362" bounds="1033 337 59 51" textPosition="1033 364"> <Properties> <displayName>MIR132 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="2998" reactomeId="9615489" position="994 284" bounds="943 259 103 50" textPosition="946 273" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S133-CREB1:MIR132 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="3103" reactomeId="9615528" position="672 1262" bounds="641 1237 63 51" textPosition="643 1264"> <Properties> <displayName>MIR137 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="3104" reactomeId="452271" position="631 1216" bounds="611 1205 40 22" textPosition="611 1205"> <Properties> <displayName>SOX2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3105" reactomeId="9615538" position="790 1346" bounds="746 1328 88 36" textPosition="746 1328" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:SOX2:MIR137 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="3187" reactomeId="9615669" position="696 1494" bounds="651 1483 91 22" textPosition="652 1483" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>miR-137 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableRNA id="3233" reactomeId="2318746" position="723 1543" bounds="680 1525 87 36" textPosition="685 1532"> <Properties> <displayName>PTEN mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="3234" reactomeId="9615784" position="493 1509" bounds="446 1493 95 33" textPosition="449 1490" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PTEN mRNA:miR-137 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3255" reactomeId="199420" position="379 1552" bounds="359 1541 40 22" textPosition="361 1541"> <Properties> <displayName>PTEN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="3324" reactomeId="9615805" position="471 1350" bounds="449 1325 45 51" textPosition="448 1352"> <Properties> <displayName>IRAK1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="3325" reactomeId="9615814" position="601 1382" bounds="563 1364 77 37" textPosition="563 1365" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MECP2:IRAK1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3353" reactomeId="446639" position="391 1486" bounds="369 1475 44 22" textPosition="369 1475"> <Properties> <displayName>IRAK1</displayName> </Properties> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="8986943" points="1819 575, 1853 539, 1956 538" position="1853 539" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="869 507" /> <Input id="4" points="1972 598" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>MECP2 binds MET gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7" reactomeId="8986940" points="1972 598, 2025 604, 2338 601" position="2025 604" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="4" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Activators> <Activator id="5" points="2009 558" /> </Activators> <Properties> <displayName>MET gene transcription is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="8986937" points="586 1017, 677 1043, 761 1060" position="677 1043" lineWidth="1.0"> <Inputs> <Input id="15" points="620 998" /> <Input id="3" points="826 525" /> </Inputs> <Outputs> <Output id="16" points="796 1097" /> <Output id="17" points="805 1052" /> </Outputs> <Catalysts> <Catalyst id="18" points="671 1091" /> </Catalysts> <Properties> <displayName>MECP2 is phosphorylated at T308</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="8986939" points="568 933, 568 1099, 565 1146" position="568 1099" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="55" points="549 902" /> <Input id="3" points="824 525" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Inhibitors> <Inhibitor id="18" points="629 1112" /> </Inhibitors> <Properties> <displayName>MECP2 binds the NCoR/SMRT complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="9005995" points="720 539, 715 521, 701 498" position="715 521" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" stoichiometry="3" points="798 513" /> <Input id="2203" points="681 541" /> </Inputs> <Outputs> <Output id="2205" /> </Outputs> <Properties> <displayName>MECP2 binds the SIN3A co-repressor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="156" reactomeId="9005988" points="1784 828, 1870 812, 1918 817" position="1870 812" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="157" points="1881 845" /> <Input id="3" points="869 517, 1689 862" /> </Inputs> <Outputs> <Output id="158" /> </Outputs> <Properties> <displayName>MECP2 binds the TRPC3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="221" reactomeId="9005994" points="1881 845, 1988 879, 2290 869" position="1988 879" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="157" /> </Inputs> <Outputs> <Output id="222" /> </Outputs> <Activators> <Activator id="158" points="1986 840" /> </Activators> <Properties> <displayName>TRPC3 gene transcription is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="9006050" points="481 475, 502 436, 545 408" position="502 436" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2207" points="515 472" /> <Input id="228" points="408 450" /> </Inputs> <Outputs> <Output id="229" /> </Outputs> <Properties> <displayName>MECP2:SIN3A complex binds the promoter of the BDNF gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="242" reactomeId="9006122" points="408 450, 463 371, 482 75" position="463 371" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="228" /> </Inputs> <Outputs> <Output id="243" /> </Outputs> <Inhibitors> <Inhibitor id="229" points="507 377" /> </Inhibitors> <Activators> <Activator id="3" points="814 485, 631 354, 530 326" /> </Activators> <Properties> <displayName>BDNF gene transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="399" reactomeId="9006503" points="1257 1098, 1218 1133, 1201 1248" position="1218 1133" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="400" points="1292 1121" /> <Input id="3" points="846 525, 1265 939" /> </Inputs> <Outputs> <Output id="401" /> </Outputs> <Properties> <displayName>MECP2 binds the PVALB gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="436" reactomeId="9006508" points="1292 1121, 1294 1282, 1245 1516" position="1294 1282" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="400" /> </Inputs> <Outputs> <Output id="445" /> </Outputs> <Inhibitors> <Inhibitor id="401" points="1249 1275" /> </Inhibitors> <Properties> <displayName>PVALB gene expression is repressed by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="483" reactomeId="9006490" points="1643 584, 1694 614, 1766 621" position="1694 614" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="484" points="1642 622" /> <Input id="3" points="869 507" /> </Inputs> <Outputs> <Output id="485" /> </Outputs> <Properties> <displayName>MECP2 binds the GRIN2A gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="524" reactomeId="9006507" points="1642 622, 1819 689, 2331 702" position="1819 689" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="484" /> </Inputs> <Outputs> <Output id="525" /> </Outputs> <Activators> <Activator id="485" points="1816 647" /> </Activators> <Properties> <displayName>GRIN2A gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="9006588" points="1468 1179, 1465 1233, 1489 1319" position="1465 1233" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="850 525, 1458 1008" /> <Input id="528" points="1555 1217" /> </Inputs> <Outputs> <Output id="529" /> </Outputs> <Properties> <displayName>MECP2 binds the PTPN4 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="539" reactomeId="9006585" points="1555 1217, 1569 1294, 1555 1526" position="1569 1294" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="528" /> </Inputs> <Outputs> <Output id="540" /> </Outputs> <Activators> <Activator id="529" points="1522 1319" /> </Activators> <Properties> <displayName>PTPN4 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="641" reactomeId="9006992" points="678 952, 745 957, 796 957" position="745 957" lineWidth="1.0"> <Inputs> <Input id="3" points="828 525" /> <Input id="15" points="655 972" /> </Inputs> <Outputs> <Output id="644" points="873 975" /> <Output id="17" points="822 1033" /> </Outputs> <Catalysts> <Catalyst id="645" points="731 985" /> </Catalysts> <Properties> <displayName>MECP2 is phosphorylated at S423</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="646" points="715 1033, 681 1091" position="698 1062" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="645" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="687" reactomeId="9017447" points="442 1168, 442 1221, 428 1266" position="442 1221" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="817 525, 437 872" /> <Input id="2649" points="349 1264" /> </Inputs> <Outputs> <Output id="689" /> </Outputs> <Properties> <displayName>MECP2 binds PPARG gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="716" reactomeId="9017441" points="349 1264, 351 1357, 342 1391" position="351 1357" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2649" /> </Inputs> <Outputs> <Output id="717" /> </Outputs> <Inhibitors> <Inhibitor id="689" points="406 1306" /> </Inhibitors> <Properties> <displayName>PPARG gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="814" reactomeId="9017921" points="1736 1174, 1974 1188, 2326 1196" position="1974 1188" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="735" /> </Inputs> <Outputs> <Output id="815" /> </Outputs> <Inhibitors> <Inhibitor id="923" points="1979 1230" /> </Inhibitors> <Properties> <displayName>OPRM1 gene expression is repressed by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="922" reactomeId="9017954" points="1759 1254, 1825 1252, 1926 1255" position="1825 1252" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="435 559, 25 628, 25 1626, 1745 1633" /> <Input id="735" points="1736 1174" /> </Inputs> <Outputs> <Output id="923" /> </Outputs> <Properties> <displayName>MECP2:SIN3A complex binds OPRM1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="964" reactomeId="9017983" points="803 361, 819 345, 826 317" position="819 345" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="830 485" /> <Input id="965" points="774 331" /> </Inputs> <Outputs> <Output id="966" /> </Outputs> <Properties> <displayName>MECP2 binds CRH gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="997" reactomeId="9017988" points="774 331, 761 289, 763 74" position="761 289" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="965" /> </Inputs> <Outputs> <Output id="998" /> </Outputs> <Inhibitors> <Inhibitor id="966" points="793 292" /> </Inhibitors> <Properties> <displayName>CRH gene expression is repressed by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="999" reactomeId="9018594" points="1219 289, 1315 267, 1349 245" position="1315 267" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1000" points="1271 241" /> <Input id="3" points="869 493, 1089 401" /> </Inputs> <Outputs> <Output id="1001" /> </Outputs> <Properties> <displayName>MECP2 binds LBR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1016" reactomeId="9020504" points="1717 737, 1825 725, 1890 725" position="1825 725" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1017" points="1727 769" /> <Input id="3" points="869 512" /> </Inputs> <Outputs> <Output id="1018" /> </Outputs> <Properties> <displayName>MECP2 binds GRIN2B gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1069" reactomeId="9020513" points="1727 769, 1965 782, 2338 775" position="1965 782" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1017" /> </Inputs> <Outputs> <Output id="1070" /> </Outputs> <Inhibitors> <Inhibitor id="1018" points="1960 740" /> </Inhibitors> <Properties> <displayName>GRIN2B gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1095" reactomeId="9021182" points="1057 128, 1054 145, 1058 173" position="1054 145" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1096" points="1128 131" /> <Input id="1204" points="992 130" /> </Inputs> <Outputs> <Output id="1098" /> </Outputs> <Properties> <displayName>MECP2 mRNA binds miR-132 RISC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1099" reactomeId="9021183" points="937 149, 922 188, 836 485" position="922 188" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1204" /> </Inputs> <Outputs> <Output id="3" /> </Outputs> <Inhibitors> <Inhibitor id="1098" points="965 188" /> </Inhibitors> <Properties> <displayName>MECP2 mRNA translation is inhibited by miR-132</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1266" reactomeId="9021851" points="430 630, 439 667, 438 710" position="439 667" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="809 525, 540 676" /> <Input id="1267" points="359 599" /> </Inputs> <Outputs> <Output id="1268" /> </Outputs> <Properties> <displayName>MECP2 binds CREB1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1281" reactomeId="9021847" points="359 599, 341 701, 314 729" position="341 701" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1267" /> </Inputs> <Outputs> <Output id="1282" /> </Outputs> <Activators> <Activator id="1268" points="392 718" /> </Activators> <Properties> <displayName>CREB1 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1337" reactomeId="9021888" points="898 198, 880 157, 843 28, 35 26, 35 693, 208 691" position="880 157" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2996" points="944 374" /> <Input id="3" points="835 485" /> </Inputs> <Outputs> <Output id="1338" /> </Outputs> <Properties> <displayName>MECP2 binds CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1398" reactomeId="9021919" points="290 447, 348 406, 377 370" position="348 406" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1399" points="265 444" /> <Input id="1338" points="245 664" /> </Inputs> <Outputs> <Output id="1400" /> </Outputs> <Properties> <displayName>MECP2:CREB1 binds SST gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1423" reactomeId="9021935" points="265 444, 255 310, 297 73" position="255 310" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1399" /> </Inputs> <Outputs> <Output id="1424" /> </Outputs> <Activators> <Activator id="1400" points="364 330" /> </Activators> <Properties> <displayName>SST gene expression is stimulated by MECP2 and CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1659" reactomeId="9021954" points="1809 909, 1892 926, 1960 934" position="1892 926" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="859 525, 1579 899" /> <Input id="1660" points="1774 938" /> </Inputs> <Outputs> <Output id="1661" /> </Outputs> <Properties> <displayName>MECP2 binds OPRK1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1666" reactomeId="9021951" points="1774 938, 2006 996, 2335 975" position="2006 996" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1660" /> </Inputs> <Outputs> <Output id="1667" /> </Outputs> <Activators> <Activator id="1661" points="2005 958" /> </Activators> <Properties> <displayName>OPRK1 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1668" reactomeId="9021945" points="1055 1173, 1085 1200, 1066 1242" position="1085 1200" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1669" points="973 1257" /> <Input id="3" points="844 525, 1190 950" /> </Inputs> <Outputs> <Output id="1670" /> </Outputs> <Properties> <displayName>MECP2 binds GAMT gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1671" reactomeId="9021953" points="973 1257, 979 1316, 993 1490" position="979 1316" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1669" /> </Inputs> <Outputs> <Output id="1672" /> </Outputs> <Activators> <Activator id="1670" points="1031 1284" /> </Activators> <Properties> <displayName>GAMT gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1673" reactomeId="9021946" points="1716 1008, 1817 1027, 1872 1027" position="1817 1027" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="854 525, 1589 999" /> <Input id="1674" points="1711 1033" /> </Inputs> <Outputs> <Output id="1675" /> </Outputs> <Properties> <displayName>MECP2 binds GPRIN1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1676" reactomeId="9021948" points="1711 1033, 1922 1087, 2331 1061" position="1922 1087" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1674" /> </Inputs> <Outputs> <Output id="1677" /> </Outputs> <Activators> <Activator id="1675" points="1920 1047" /> </Activators> <Properties> <displayName>GPRIN1 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1734" reactomeId="9021950" points="378 883, 357 954, 343 990" position="357 954" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="816 525" /> <Input id="1735" points="244 933" /> </Inputs> <Outputs> <Output id="1736" /> </Outputs> <Properties> <displayName>MECP2 binds MEF2C gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1737" reactomeId="9021949" points="244 933, 256 995, 234 1073" position="256 995" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1735" /> </Inputs> <Outputs> <Output id="1738" /> </Outputs> <Inhibitors> <Inhibitor id="1736" points="293 1001" /> </Inhibitors> <Properties> <displayName>MEF2C gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1823" reactomeId="9021944" points="406 1057, 372 1055, 337 1081" position="372 1055" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1824" points="390 1155" /> <Input id="3" points="816 525, 414 871" /> </Inputs> <Outputs> <Output id="1825" /> </Outputs> <Properties> <displayName>MECP2 binds RBFOX1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1826" reactomeId="9021952" points="390 1155, 315 1147, 285 1157" position="315 1147" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1824" /> </Inputs> <Outputs> <Output id="1827" /> </Outputs> <Inhibitors> <Inhibitor id="1825" points="316 1119" /> </Inhibitors> <Properties> <displayName>RBFOX1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1939" reactomeId="9022175" points="1822 349, 1861 281, 1899 276" position="1861 281" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1338" points="208 684, 48 649, 59 4, 1776 13" /> <Input id="1940" points="1901 334" /> </Inputs> <Outputs> <Output id="1941" /> </Outputs> <Properties> <displayName>MECP2:CREB1 complex binds SLC2A3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1946" reactomeId="9022186" points="1901 334, 1977 343, 2333 350" position="1977 343" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1940" /> </Inputs> <Outputs> <Output id="1947" /> </Outputs> <Activators> <Activator id="1941" points="1976 289" /> </Activators> <Properties> <displayName>SLC2A3 gene expression is stimulated by MECP2:CREB1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2036" reactomeId="9022314" points="722 937, 786 930, 818 926" position="786 930" lineWidth="1.0"> <Inputs> <Input id="3" points="829 525" /> <Input id="15" points="665 975" /> </Inputs> <Outputs> <Output id="2038" points="861 916" /> <Output id="17" points="826 1033" /> </Outputs> <Catalysts> <Catalyst id="2040" points="836 873" /> </Catalysts> <Properties> <displayName>HIPK2 phosphorylates MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2041" reactomeId="9022315" points="878 827, 887 779, 868 733" position="887 779" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2042" points="844 820" /> <Input id="2038" points="911 890" /> </Inputs> <Outputs> <Output id="2043" /> </Outputs> <Properties> <displayName>MECP2 binds DGCR8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2178" reactomeId="9022359" points="1804 429, 1836 417, 1894 419" position="1836 417" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="435 555, 74 591, 74 12, 1767 26" /> <Input id="2179" points="1797 490" /> </Inputs> <Outputs> <Output id="2180" /> </Outputs> <Properties> <displayName>MECP2:SIN3A complex binds GRIA2 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2181" reactomeId="9022365" points="1797 490, 1948 487, 2328 483" position="1948 487" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2179" /> </Inputs> <Outputs> <Output id="2182" /> </Outputs> <Inhibitors> <Inhibitor id="2180" points="1947 450" /> </Inhibitors> <Properties> <displayName>GRIA2 gene expression is inhibited by MECP2:SIN3A complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="2206" points="534 528, 634 488" position="584 508" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="70" /> </Inputs> <Outputs> <Output id="2205" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="2208" points="612 469, 634 469" position="623 469" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="2207" /> </Inputs> <Outputs> <Output id="2205" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="2272" reactomeId="9022456" points="1333 433, 1336 402, 1330 315" position="1336 402" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="869 500" /> <Input id="2273" points="1291 363" /> </Inputs> <Outputs> <Output id="2274" /> </Outputs> <Properties> <displayName>MECP2 binds 5mC-DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2275" reactomeId="9022453" points="1369 453, 1377 427, 1410 397" position="1377 427" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="869 502" /> <Input id="2276" points="1392 445" /> </Inputs> <Outputs> <Output id="2277" /> </Outputs> <Properties> <displayName>MECP2 binds 5hmC-DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2369" reactomeId="9022625" points="1147 424, 1180 415, 1223 410" position="1180 415" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="869 497" /> <Input id="2370" points="1182 373" /> </Inputs> <Outputs> <Output id="2371" /> </Outputs> <Properties> <displayName>MECP2 binds FOXG1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2471" reactomeId="9022734" points="1631 1243, 1599 1314, 1617 1376" position="1599 1314" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="852 525, 1578 1051" /> <Input id="2472" points="1700 1273" /> </Inputs> <Outputs> <Output id="2473" /> </Outputs> <Properties> <displayName>MECP2 binds FKBP5 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2474" reactomeId="9022728" points="1700 1273, 1711 1400, 1702 1502" position="1711 1400" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2472" /> </Inputs> <Outputs> <Output id="2475" /> </Outputs> <Inhibitors> <Inhibitor id="2473" points="1664 1398" /> </Inhibitors> <Properties> <displayName>FKBP5 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2575" reactomeId="9022770" points="1050 1035, 1013 1130, 974 1164" position="1013 1130" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="842 525, 1118 934" /> <Input id="2576" points="896 1167" /> </Inputs> <Outputs> <Output id="2577" /> </Outputs> <Properties> <displayName>MECP2 binds SGK1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2578" reactomeId="9022764" points="896 1167, 879 1288, 864 1493" position="879 1288" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2576" /> </Inputs> <Outputs> <Output id="2579" /> </Outputs> <Inhibitors> <Inhibitor id="2577" points="943 1205" /> </Inhibitors> <Properties> <displayName>SGK1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2677" reactomeId="9022935" points="1580 457, 1603 439, 1608 346" position="1603 439" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="869 503" /> <Input id="2678" points="1553 390" /> </Inputs> <Outputs> <Output id="2679" /> </Outputs> <Properties> <displayName>MECP2 binds GAD1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2685" reactomeId="9022934" points="1553 390, 1535 339, 1483 217" position="1535 339" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2678" /> </Inputs> <Outputs> <Output id="2686" /> </Outputs> <Activators> <Activator id="2679" points="1568 331" /> </Activators> <Properties> <displayName>GAD1 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2688" reactomeId="9022941" points="1708 474, 1727 460, 1727 319" position="1727 460" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2689" points="1686 382" /> <Input id="3" points="869 503" /> </Inputs> <Outputs> <Output id="2690" /> </Outputs> <Properties> <displayName>MECP2 binds GAD2 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2691" reactomeId="9022942" points="1686 382, 1645 281, 1634 220" position="1645 281" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2689" /> </Inputs> <Outputs> <Output id="2692" /> </Outputs> <Activators> <Activator id="2690" points="1684 290" /> </Activators> <Properties> <displayName>GAD2 gene expression is stimulated by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2740" reactomeId="9022872" points="1110 1304, 1147 1314, 1161 1359" position="1147 1314" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2741" points="1085 1304" /> <Input id="3" points="845 525, 1226 945" /> </Inputs> <Outputs> <Output id="2742" /> </Outputs> <Properties> <displayName>MECP2 binds MOBP gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2743" reactomeId="9022870" points="1085 1304, 1090 1378, 1102 1495" position="1090 1378" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2741" /> </Inputs> <Outputs> <Output id="2744" /> </Outputs> <Inhibitors> <Inhibitor id="2742" points="1127 1379" /> </Inhibitors> <Properties> <displayName>MOBP gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2815" reactomeId="9023346" points="1652 1097, 1751 1120, 1871 1120" position="1751 1120" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="852 525, 1596 1041" /> <Input id="2816" points="1696 1122" /> </Inputs> <Outputs> <Output id="2817" /> </Outputs> <Properties> <displayName>MECP2 binds NOTCH1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2818" reactomeId="9023345" points="1696 1122, 1924 1170, 2103 1138" position="1924 1170" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2816" /> </Inputs> <Outputs> <Output id="2819" /> </Outputs> <Inhibitors> <Inhibitor id="2817" points="1923 1141" /> </Inhibitors> <Properties> <displayName>NOTCH1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2873" reactomeId="9023348" points="654 325, 693 326, 688 295" position="693 326" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="819 485" /> <Input id="2874" points="628 273" /> </Inputs> <Outputs> <Output id="2875" /> </Outputs> <Properties> <displayName>MECP2 binds DLL1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2881" reactomeId="9023351" points="628 273, 616 186, 576 113" position="616 186" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2874" /> </Inputs> <Outputs> <Output id="2882" /> </Outputs> <Inhibitors> <Inhibitor id="2875" points="685 253, 683 190" /> </Inhibitors> <Properties> <displayName>DLL1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2906" interactionType="Activate" points="593 99, 614 100" position="603 99" lineWidth="2.0"> <Inputs> <Input id="2882" /> </Inputs> <Outputs> <Output id="2905" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2908" interactionType="Activate" points="2216 1128, 2249 1128" position="2232 1128" lineWidth="2.0"> <Inputs> <Input id="2819" /> </Inputs> <Outputs> <Output id="2907" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2921" reactomeId="9023132" points="663 921, 761 947, 785 964" position="761 947" lineWidth="1.0"> <Inputs> <Input id="3" points="827 525" /> <Input id="15" points="646 972" /> </Inputs> <Outputs> <Output id="644" points="860 975" /> <Output id="17" points="820 1033" /> </Outputs> <Catalysts> <Catalyst id="2924" points="777 888" /> </Catalysts> <Properties> <displayName>AURKB phosphorylates MECP2 at S423</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2965" reactomeId="9023538" points="1426 1117, 1431 1317, 1432 1371" position="1431 1317" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="848 525, 1402 1011" /> <Input id="2966" points="1385 1052" /> </Inputs> <Outputs> <Output id="2967" /> </Outputs> <Properties> <displayName>MECP2 binds PTPN1 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2978" reactomeId="9023549" points="1385 1052, 1360 1377, 1373 1520" position="1360 1377" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2966" /> </Inputs> <Outputs> <Output id="2979" /> </Outputs> <Inhibitors> <Inhibitor id="2967" points="1386 1382" /> </Inhibitors> <Properties> <displayName>PTPN1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2980" reactomeId="9023592" points="581 631, 556 626, 511 617" position="556 626" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2981" points="579 604" /> <Input id="3" points="805 525" /> </Inputs> <Outputs> <Output id="2982" /> </Outputs> <Properties> <displayName>MECP2 binds HTT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2995" reactomeId="9615490" points="999 354, 989 336, 991 312" position="989 336" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2996" points="970 374" /> <Input id="2997" points="1101 339" /> </Inputs> <Outputs> <Output id="2998" /> </Outputs> <Properties> <displayName>p-S133-CREB1 binds MIR132 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3033" reactomeId="9615501" points="1101 339, 1173 277, 1182 152" position="1173 277" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="2997" /> </Inputs> <Outputs> <Output id="1096" /> </Outputs> <Activators> <Activator id="2998" points="1049 281" /> </Activators> <Properties> <displayName>MIR132 gene expression is stimulated by p-S133-CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3102" reactomeId="9615536" points="869 1147, 785 1228, 789 1325" position="785 1228" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="839 525, 1057 957" /> <Input id="3103" points="713 1239" /> <Input id="3104" points="654 1210" /> </Inputs> <Outputs> <Output id="3105" /> </Outputs> <Properties> <displayName>MECP2 and SOX2 bind MIR137 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3186" reactomeId="9615554" points="713 1239, 703 1346, 696 1477" position="703 1346" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3103" /> </Inputs> <Outputs> <Output id="3187" /> </Outputs> <Inhibitors> <Inhibitor id="3105" points="743 1346" /> </Inhibitors> <Properties> <displayName>MIR137 gene expression is inhibited by MECP2 and SOX2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3232" reactomeId="9615570" points="611 1510, 589 1511, 544 1509" position="589 1511" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3187" points="645 1502" /> <Input id="3233" points="677 1530" /> </Inputs> <Outputs> <Output id="3234" /> </Outputs> <Properties> <displayName>miR-137 binds PTEN mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3254" reactomeId="9615571" points="677 1545, 493 1555, 402 1552" position="493 1555" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3233" /> </Inputs> <Outputs> <Output id="3255" /> </Outputs> <Inhibitors> <Inhibitor id="3234" points="493 1529" /> </Inhibitors> <Properties> <displayName>PTEN mRNA translation is inhibited by miR-137</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3323" reactomeId="9615801" points="509 1274, 557 1317, 588 1361" position="557 1317" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="818 525, 458 876" /> <Input id="3324" points="503 1327" /> </Inputs> <Outputs> <Output id="3325" /> </Outputs> <Properties> <displayName>MECP2 binds IRAK1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3352" reactomeId="9615829" points="503 1327, 516 1402, 407 1472" position="516 1402" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="3324" /> </Inputs> <Outputs> <Output id="3353" /> </Outputs> <Inhibitors> <Inhibitor id="3325" points="560 1391" /> </Inhibitors> <Properties> <displayName>IRAK1 gene expression is inhibited by MECP2</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Transcriptional Regulation by MECP2, Loss of MECP2 binding ability to 5mC-DNA, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of MECP2 binding ability to 5hmC-DNA, and Loss of phosphorylation of MECP2 at T308 (9005582)
