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Details on Person Inferred from rat, mouse, human :Tyrosine protein kinase JAK...

Class:IdSummation:9005487
_displayNameInferred from rat, mouse, human :Tyrosine protein kinase JAK...
_timestamp2017-07-04 12:25:43
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:9005462] Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
[LiteratureReference:9005483] Therapeutic opportunities of the IL-22-IL-22R1 system
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009475] Duenas, Corina, 2017-06-19
[InstanceEdit:9009675] Duenas, Corina, 2017-06-22
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9010942] Duenas, Corina, 2017-06-28
[InstanceEdit:9011073] Duenas, Corina, 2017-06-29
[InstanceEdit:9011686] Duenas, Corina, 2017-07-04
textInferred from rat, mouse, human :Tyrosine protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-22 interacts with its receptor. The receptor is a complex formed by Interleukin-22 receptor subunit alpha-1 (IL22RA1), JAK1, Interleukin-10 receptor subunit beta (IL10RB) and TYK2 (Lejeune et al. 2002, Sabat et al. 2014). This is a black-box event because the JAK1/TYK2 coordinates phosphorylated after IL22 stimulus are unknown.
(summation)[BlackBoxEvent:8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 [Homo sapiens]
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