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Details on Person Signal transducer and activator of transcription 3 (STAT3) b...
| Class:Id | Summation:9005485 |
|---|---|
| _displayName | Signal transducer and activator of transcription 3 (STAT3) b... |
| _timestamp | 2017-06-15 16:16:37 |
| created | [InstanceEdit:9005452] Duenas, Corina, 2017-05-09 |
| literatureReference | [LiteratureReference:8987116] Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 [LiteratureReference:6783812] Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain [LiteratureReference:9009139] The cationic cytokine IL-26 differentially modulates virus infection in culture [LiteratureReference:8987171] The Structural Basis for Class II Cytokine Receptor Recognition by JAK1 |
| modified | [InstanceEdit:9006768] Duenas, Corina, 2017-05-19 [InstanceEdit:9009145] Duenas, Corina, 2017-06-15 |
| text | Signal transducer and activator of transcription 3 (STAT3) binds to Interleukin‑26 (IL26) activated receptor complex. This is a black box event since there is no evidence that STAT3 binds to the receptor complex before being phosphorylated, but following other interleukin signaling cascades as IL10 (Weber-Nordt et al. 1996) this step should happens before its activation (Braum et al. 2013). JAK1 association is also infered from other interleukin cascades because it has been described cytokine receptor type II (as IL20RA) has a domain which is essential for JAK1 binding and activation of cascade signaling (Ferrao et al. 2016). This activated receptor complex is formed by IL26 ligand associated to Interleukin‑10 receptor subunit beta (IL10RB), phosphorylated Non‑receptor tyrosine‑protein kinase TYK2 (TYK2), Interleukin‑20 receptor subunit alpha (IL20RA) and phosphorylated Tyrosine‑protein kinase JAK1 (JAK1) (Sheikh et al. 2004). |
| (summation) | [BlackBoxEvent:8987237] IL26:IL10RB:p‑TYK2:IL20RA:p‑JAK1 binds STAT3 [Homo sapiens] |
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No pathways have been reviewed or authored by Signal transducer and activator of transcription 3 (STAT3) b... (9005485)
