Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosin...

Class:IdSummation:9005447
_displayNameTyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosin...
_timestamp2017-07-04 16:29:11
created[InstanceEdit:9005452] Duenas, Corina, 2017-05-09
literatureReference[LiteratureReference:6783849] IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes
[LiteratureReference:6784349] Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex
[LiteratureReference:9005467] Structure and mechanism of receptor sharing by the IL-10R2 common chain
[LiteratureReference:8987171] The Structural Basis for Class II Cytokine Receptor Recognition by JAK1
modified[InstanceEdit:9006768] Duenas, Corina, 2017-05-19
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009675] Duenas, Corina, 2017-06-22
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011073] Duenas, Corina, 2017-06-29
[InstanceEdit:9011689] Duenas, Corina, 2017-07-04
[InstanceEdit:9011706] Jupe, Steve, 2017-07-04
textTyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-26 (IL26) ligand/receptor interaction. The Interleukin-10 receptor subunit beta (IL10RB) component of the IL26 receptor is also a component of the IL10 receptor, where it associates with TYK2 (Finbloom & Winestock 1995). The Interleukin-20 receptor subunit alpha (IL20RA) component of the IL26 receptor, like the Interleukin-10 receptor subunit alpha (IL10RA) subunit of the IL10 receptor, is a type II cytokine receptor, suggested by homology with IL10RA to be capable of binding JAK1 (Ferrao et al. 2016). Structural models of the IL10 receptor suggest that the space between the two receptor subunits is occupied by JAK1 and TYK2 (Yoon et al. 2006, 2010). Taken together, these observations suggest that IL26 receptor signaling involves JAK1 and TYK2 activation.
(summation)[BlackBoxEvent:8986994] IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosin... (9005447)
Follow Reactome